Advances and recent developments in asthma in 2020

被引：149

作者：

Cevhertas, Lacin ^{[1
,2
,3
]}

Ogulur, Ismail ^{[1
,4
]}

Maurer, Debbie J. ^{[1
]}

Burla, Daniel ^{[1
]}

Ding, Mei ^{[1
,2
,5
]}

Jansen, Kirstin ^{[1
]}

Koch, Jana ^{[1
,6
]}

Liu, Chengyao ^{[1
,7
]}

Ma, Siyuan ^{[1
,7
]}

Mitamura, Yasutaka ^{[1
]}

Peng, Yaqi ^{[1
,8
]}

Radzikowska, Urszula ^{[1
,2
,9
]}

Rinaldi, Arturo O. ^{[1
]}

Satitsuksanoa, Pattraporn ^{[1
,2
]}

Globinska, Anna ^{[1
]}

van de Veen, Willem ^{[1
,2
]}

Sokolowska, Milena ^{[1
]}

Baerenfaller, Katja ^{[1
,6
]}

Gao, Ya-dong

Agache, Ioana ^{[10
]}

Akdis, Muebeccel ^{[1
]}

Akdis, Cezmi A. ^{[1
,2
]}

机构：

[1] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[2] Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland

[3] Bursa Uludag Univ, Inst Hlth Sci, Dept Med Immunol, Bursa, Turkey

[4] Marmara Univ, Div Pediat Allergy & Immunol, Fac Med, Istanbul, Turkey

[5] Wuhan Univ, Zhongnan Hosp, Dept Allergol, Wuhan, Hubei, Peoples R China

[6] Swiss Inst Bioinformat SIB, Davos, Switzerland

[7] Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

[8] Sun Yat Sen Univ, Affiliated Hosp 1, Otorhinolaryngol Hosp, Guangzhou, Peoples R China

[9] Med Univ Bialystok, Dept Regenerat Med & Immune Regulat, Bialystok, Poland

[10] Transylvania Univ, Fac Med, Brasov, Romania

来源：

ALLERGY | 2020年 / 75卷 / 12期

关键词：

asthma biomarkers; asthma phenotypes; biological therapeutics; comorbidities; COVID-19; ALLERGEN IMMUNOTHERAPY; CLINICAL CHARACTERISTICS; ARGINASE INHIBITORS; BLOOD EOSINOPHILS; EAACI GUIDELINES; FOOD ALLERGY; RHINITIS; MANAGEMENT; OMALIZUMAB; PATHOLOGY;

D O I：

10.1111/all.14607

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.

引用

页码：3124 / 3146

页数：23

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