Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

被引：17
作者：
Chen, Yan-Mei [1 ]
Li, Chen [1 ]
Zhang, Wen-Jing [1 ]
Shi, Yan [1 ]
Wen, Zi-Jie [1 ]
Chen, Qing-Xi [1 ]
Wang, Qin [1 ]
机构：
[1] Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2019年 / 34卷 / 01期
基金：
美国国家科学基金会;
关键词：
Kojic acid derivatives; tyrosinase inhibition; antioxidant; CATECHOLASE ACTIVITY; SERUM-ALBUMIN; INHIBITION; ANTITYROSINASE; ANALOGS; BINDING;
D O I：
10.1080/14756366.2019.1609467
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS(+) assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents.
引用
收藏
页码：990 / 998
页数：9
相关论文
共 50 条
  • [31] Design, Synthesis, and Biological Evaluation of Dexibuprofen Derivatives as Novel Anti-Inflammatory, Antioxidant and Molecular Docking Studies
    Raza, Asim
    Abbas Khan, Mohsin
    Ahmad, Irshad
    Ur Rehman, Sajid
    Khaliq, Saharish
    Ahmed, Javed
    Awan, Breena
    Ullah, Farhat
    Masood, Anum
    Ahmed, Naveed
    CHEMISTRY & BIODIVERSITY, 2023, 20 (07)
  • [32] Synthesis and Molecular Docking Study of Bis-Indolylmethane Thiourea Derivatives as Anti-Alzheimer Agents
    Ullah, H.
    Bibi, U.
    Hussain, A.
    Sarfraz, M.
    Rahim, F.
    Hayat, S.
    Zada, H.
    Khan, F.
    Wadood, A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2023, 59 (01) : 181 - 189
  • [33] NEW BIARYL DERIVATIVES OF DICLOFENAC DRUG: SYNTHESIS, MOLECULAR DOCKING AND THEIR BIOLOGICAL ACTIVITY STUDY AS ANTICANCER AND ANTIOXIDANT AGENTS
    Abdul-Rida, N. A.
    Mohammed, K. T.
    IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 2024, 67 (12): : 47 - 53
  • [34] Synthesis, biological evaluation and molecular docking studies of N-acylheteroaryl hydrazone derivatives as antioxidant and anti-inflammatory agents
    Pravin S. Mahajan
    Mukesh D. Nikam
    Vijay M. Khedkar
    Prakash C. Jha
    Dhiman Sarkar
    Charansingh H. Gill
    Research on Chemical Intermediates, 2016, 42 : 2707 - 2729
  • [35] Synthesis, Molecular Docking and Biological Evaluation of N-Substituted Indole Derivatives as Potential Anti-Inflammatory and Antioxidant Agents
    Kumari, Archana
    Singh, Rajesh Kumar
    CHEMISTRY & BIODIVERSITY, 2022, 19 (09)
  • [36] Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity
    Rosada, Beata
    Bekier, Adrian
    Cytarska, Joanna
    Plazinski, Wojciech
    Zavyalova, Olga
    Sikora, Adam
    Dzitko, Katarzyna
    Laczkowski, Krzysztof Z.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 184
  • [37] Synthesis, biological evaluation and molecular docking studies of N-acylheteroaryl hydrazone derivatives as antioxidant and anti-inflammatory agents
    Mahajan, Pravin S.
    Nikam, Mukesh D.
    Khedkar, Vijay M.
    Jha, Prakash C.
    Sarkar, Dhiman
    Gill, Charansingh H.
    RESEARCH ON CHEMICAL INTERMEDIATES, 2016, 42 (03) : 2707 - 2729
  • [38] Synthesis of Some Novel 2-Substitutedbenzyl-(4)7-phenyl-1H-benzo[d]imidazoles in Mild Conditions as Potent Anti-Tyrosinase and Antioxidant Agents
    Dogan, Inci S.
    Ozel, Arzu
    Birinci, Zeynep
    Barut, Burak
    Sellitepe, Hasan E.
    Kahveci, Bahittin
    ARCHIV DER PHARMAZIE, 2016, 349 (11) : 881 - 888
  • [39] Biotransformation of isocostic acid from Dittrichia viscosa essential oil by Saccharomyces cerevisiae: in vitro anti-tyrosinase effect, insights from molecular docking and drug-likeness prediction
    Algethami, Faisal K.
    Ben Mustapha, Mayssa
    Elamin, Mohamed R.
    Abdulkhair, Babiker Y.
    Ben Jannet, Hichem
    PLANT BIOSYSTEMS, 2023, : 1132 - 1141
  • [40] Study of Novel Furocoumarin Derivatives on Anti-Vitiligo Activity, Molecular Docking and Mechanism of Action
    Niu, Chao
    Zang, Deng
    Aisa, Haji Akber
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (14)
12345