Peptide hormone precursor processing: getting sorted?

被引：30

作者：

Canaff, L

Bennett, HPJ

Hendy, GN

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H3A 1A1, Canada

[2] McGill Univ, Dept Physiol, Montreal, PQ H3A 1A1, Canada

[3] McGill Univ, Dept Human Genet, Montreal, PQ H3A 1A1, Canada

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1999年 / 156卷 / 1-2期

关键词：

proprotein convertase; carboxypeptidase; 7B2; granin;

D O I：

10.1016/S0303-7207(99)00129-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：1 / 6

页数：6

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