Synthesis and antibacterial activity of various substituted s-triazines

被引：133
作者：
Srinivas, K.
Srinivas, U.
Bhanuprakash, K.
Harakishore, K.
Murthy, U. S. N.
Rao, V. Jayathirtha
机构：
[1] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Chem Technol, Organ Chem Div 2, Hyderabad 500007, Andhra Pradesh, India
[3] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500007, Andhra Pradesh, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 11期
关键词：
s-triazine derivatives; synthesis; antibacterial activity; antifungal activity;
D O I：
10.1016/j.ejmech.2006.05.013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Series of substituted-s-triazines (1-22) were synthesized and evaluated for their in vitro antibacterial activity against six representative Gram-positive and Gram-negative bacterial strains. Many compounds have displayed comparable antibacterial activity against Bacillus sphaericus and significantly active against other tested organisms with reference to streptomycin. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1240 / 1246
页数：7
相关论文
共 34 条
[1]   Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents [J].
Agarwal, A ;
Srivastava, K ;
Puri, SK ;
Chauhan, PMS .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (03) :531-533
[2]   Synthesis, and antiprotozoal and antibacterial activities of S-substituted 4,6-dibromo- and 4,6-dichloro-2-mercaptobenzimidazoles [J].
Andrzejewska, M ;
Yepez-Mulia, L ;
Tapia, A ;
Cedillo-Rivera, R ;
Laudy, AE ;
Starosciak, BJ ;
Kazimierczuk, Z .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 21 (2-3) :323-329
[3]   Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites [J].
Baliani, A ;
Bueno, GJ ;
Stewart, ML ;
Yardley, V ;
Brun, R ;
Barrett, MP ;
Gilbert, IH .
JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (17) :5570-5579
[4]  
BARRETTA GA, 2000, TETRAHEDRON-ASYMMETR, V11, P3901
[5]  
Blackburn P, 1982, ENZYMES, VXV, P317
[6]   Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin [J].
Boojamra, CG ;
Lemoine, RC ;
Lee, JC ;
Léger, R ;
Stein, KA ;
Vernier, NG ;
Magon, A ;
Lomovskaya, O ;
Martin, PK ;
Chamberland, S ;
Lee, MD ;
Hecker, SJ ;
Lee, VJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (05) :870-874
[7]   HOW DO IMIDAZOLE GROUPS CATALYZE THE CLEAVAGE OF RNA IN ENZYME MODELS AND IN ENZYMES - EVIDENCE FROM NEGATIVE CATALYSIS [J].
BRESLOW, R .
ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (11) :317-324
[8]   New directions in antibacterial research [J].
Chu, DTW ;
Plattner, JJ ;
Katz, L .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (20) :3853-3874
[9]   Syntheses and antibacterial activity of a series of 3-(pyridine-3-yl)-2-oxazolidinone [J].
Cui, YJ ;
Dang, YX ;
Yang, YS ;
Zhang, SH ;
Ji, RY .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (02) :209-214
[10]   First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling [J].
Daines, RA ;
Pendrak, I ;
Sham, K ;
Van Aller, GS ;
Konstantinidis, AK ;
Lonsdale, JT ;
Janson, CA ;
Qiu, XY ;
Brandt, M ;
Khandekar, SS ;
Silverman, C ;
Head, MS .
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) :5-8
1234