Brief report:: Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I

被引：137

作者：

Vanhollebeke, Benoit

Truc, Philippe

Poelvoorde, Philippe

Pays, Annette

Joshi, Prashant P.

Katti, Ravindra

Jannin, Jean G.

Pays, Etienne

机构：

[1] Univ Libre Bruxelles, IBMM, Mol Parasitol Lab, B-6041 Gosselies, Belgium

[2] Inst Rech Dev, Unite Rech Trypanosomoses Africaines 117, Montpellier, France

[3] Govt Med Coll, Dept Med, Nagpur, Maharashtra, India

[4] Directorate Hlth Serv, Bombay, Maharashtra, India

[5] WHO, Communicable Dis Control Prevent & Eradicat, CH-1211 Geneva, Switzerland

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2006年 / 355卷 / 26期

关键词：

D O I：

10.1056/NEJMoa063265

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Humans have innate immunity against Trypanosoma brucei brucei that is known to involve apolipoprotein L-I (APOL1). Recently, a case of T. evansi infection in a human was identified in India. We investigated whether the APOL1 pathway was involved in this occurrence. The serum of the infected patient was found to have no trypanolytic activity, and the finding was linked to the lack of APOL1, which was due to frameshift mutations in both APOL1 alleles. Trypanolytic activity was restored by the addition of recombinant APOL1. The lack of APOL1 explained the patient's infection with T. evansi.

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页码：2752 / 2756

页数：5

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