Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines

被引：51
|
作者：
Marques, CG
Pedro, M
Simoes, MFA
Nascimento, MSJ
Pinto, MMM
Rodríguez, B
机构：
[1] Univ Lisbon, Fac Farm, CECF, P-1649019 Lisbon, Portugal
[2] Univ Porto, Fac Farm, Ctr Estudos Quim Organ, Oporto, Portugal
[3] CSIC, Inst Quim Organ, E-28006 Madrid, Spain
来源：
PLANTA MEDICA | 2002年 / 68卷 / 09期
关键词：
D O I：
10.1055/s-2002-34407
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gurke, were evaluated for their in vitro anti proliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines.
引用
收藏
页码：839 / 840
页数：2
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