Systemic vitamin C and vitamin E do not prevent photoprovocation test reactions in polymorphous light eruption

被引：10

作者：

Eberlein-König, B ^{[1
]}

Fesq, H ^{[1
]}

Abeck, D ^{[1
]}

Przybilla, B ^{[1
]}

Placzek, M ^{[1
]}

Ring, J ^{[1
]}

机构：

[1] Tech Univ Munich, Klin & Poliklin Dermatol & Allergol Biederstein, Klin Kooperationsgruppe Umweltdermatol & Allergol, GSF,TUM, D-80802 Munich, Germany

来源：

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE | 2000年 / 16卷 / 02期

关键词：

polymorphous light eruption (PLE); anti-oxidants; vitamin C; vitamin E; photoprovocation;

D O I：

10.1034/j.1600-0781.2000.d01-2.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The possible influence of oxidative stress is discussed in the pathogenesis of polymorphous light eruption (PLE), A double-blind, placebo-controlled study of prophylactic treatment with systemic administration of vitamin C (3 g/d) and E (1500 IU/d) for 8 days was undertaken in 9 patients with PLE (verum, n=4; placebo, n=5), Evaluation of the maximal effects after photoprovocation before and after intake of the antioxidants revealed a reduction of most skin reactions (overall skin reaction, papules/vesicles) in both groups with marked differences in the placebo group. The antioxidants in the doses gi, en and over the time period used did not influence the development of PLE, but might interfere with immunosuppressive effects of repeated photoprovocation tests.

引用

页码：50 / 52

页数：3

共 8 条

[1]

BERGNER T, 1993, HAUTARZT, V44, P215

[2] CONTROLLED THERAPEUTIC TRIALS IN POLYMORPHIC LIGHT ERUPTION [J].