Carnitine and Depression

被引：24

作者：

Liu, Ting ^{[1
,2
]}

Deng, Kunhong ^{[3
]}

Xue, Ying ^{[1
,2
]}

Yang, Rui ^{[1
,2
]}

Yang, Rong ^{[1
,2
]}

Gong, Zhicheng ^{[1
,2
]}

Tang, Mimi ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Inst Rat & Safe Medicat Pract, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[3] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha, Peoples R China

来源：

FRONTIERS IN NUTRITION | 2022年 / 9卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

carnitine; acylcarnitines; depression; bipolar disorder; schizophrenia; ACETYL-L-CARNITINE; SERUM CARNITINE; MULTIPLE-SCLEROSIS; BIPOLAR DISORDER; DOUBLE-BLIND; VENTRAL HIPPOCAMPUS; NEUROTROPHIC FACTOR; CANCER-PATIENTS; CHRONIC-FATIGUE; SUPPLEMENTATION;

D O I：

10.3389/fnut.2022.853058

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Depression has become one of the most common mental diseases in the world, but the understanding of its pathogenesis, diagnosis and treatments remains insufficient. Carnitine is a natural substance that exists in organisms, which can be synthesized in vivo or supplemented by intake. Relationships of carnitine with depression, bipolar disorder and other mental diseases have been reported in different studies. Several studies show that the level of acylcarnitines (ACs) changes significantly in patients with depression compared with healthy controls while the supplementation of acetyl-L-carnitine is beneficial to the treatment of depression. In this review, we aimed to clarify the effects of ACs in depressive patients and to explore whether ACs might be the biomarkers for the diagnosis of depression and provide new ideas to treat depression.

引用

页数：16

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