Control of Sindbis virus infection by antibody in interferon-deficient mice

被引：54
作者：
Byrnes, AP
Durbin, JE
Griffin, DE
机构：
[1] Johns Hopkins Med Inst, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA
[2] Ohio State Univ, Childrens Hosp, Res Fdn, Columbus, OH 43205 USA
[3] Ohio State Univ, Dept Pediat, Columbus, OH 43205 USA
来源：
JOURNAL OF VIROLOGY | 2000年 / 74卷 / 08期
关键词：
D O I：
10.1128/JVI.74.8.3905-3908.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon, Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.
引用
收藏
页码：3905 / 3908
页数：4
相关论文
共 20 条
[1]   TREATMENT OF INTRACRANIAL ALPHAVIRUS INFECTIONS IN MICE BY A COMBINATION OF SPECIFIC ANTIBODIES AND AN INTERFERON INDUCER [J].
COPPENHAVER, DH ;
SINGH, IP ;
SARZOTTI, M ;
LEVY, HB ;
BARON, S .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 52 (01) :34-40
[2]  
DESPRES P, 1995, J VIROL, V69, P7345
[3]   Targeted disruption of the mouse STAT1 results in compromised innate immunity to viral disease [J].
Durbin, JE ;
Hackenmiller, R ;
Simon, MC ;
Levy, DE .
CELL, 1996, 84 (03) :443-450
[4]   Role of interferon and interferon regulatory factors in early protection against Venezuelan equine encephalitis virus infection [J].
Grieder, FB ;
Vogel, SN .
VIROLOGY, 1999, 257 (01) :106-118
[5]   The role of antibody in recovery from alphavirus encephalitis [J].
Griffin, D ;
Levine, B ;
Tyor, W ;
Ubol, S ;
Despres, P .
IMMUNOLOGICAL REVIEWS, 1997, 159 :155-161
[6]   ROLE OF IMMUNE-RESPONSE IN AGE-DEPENDENT RESISTANCE OF MICE TO ENCEPHALITIS DUE TO SINDBIS VIRUS [J].
GRIFFIN, DE .
JOURNAL OF INFECTIOUS DISEASES, 1976, 133 (04) :456-464
[7]  
HACKBARTH SA, 1973, J RETICULOENDOTH SOC, V14, P405
[8]   A NULL MUTATION IN THE GENE ENCODING A TYPE-I INTERFERON RECEPTOR COMPONENT ELIMINATES ANTIPROLIFERATIVE AND ANTIVIRAL RESPONSES TO INTERFERON-ALPHA AND INTERFERON-BETA AND ALTERS MACROPHAGE RESPONSES [J].
HWANG, SY ;
HERTZOG, PJ ;
HOLLAND, KA ;
SUMARSONO, SH ;
TYMMS, MJ ;
HAMILTON, JA ;
WHITTY, G ;
BERTONCELLO, I ;
KOLA, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11284-11288
[9]   ANTIBODY-MEDIATED CLEARANCE OF ALPHAVIRUS INFECTION FROM NEURONS [J].
LEVINE, B ;
HARDWICK, JM ;
TRAPP, BD ;
CRAWFORD, TO ;
BOLLINGER, RC ;
GRIFFIN, DE .
SCIENCE, 1991, 254 (5033) :856-860
[10]   MOLECULAR-BASIS OF SINDBIS VIRUS NEUROVIRULENCE IN MICE [J].
LUSTIG, S ;
JACKSON, AC ;
HAHN, CS ;
GRIFFIN, DE ;
STRAUSS, EG ;
STRAUSS, JH .
JOURNAL OF VIROLOGY, 1988, 62 (07) :2329-2336
12