Agranulocytosis and vasculitis in a cocaine addict: Levamisole, the hidden culprit

被引：6

作者：

Lemaignen, A. ^{[1
]}

Goulenok, T. ^{[1
]}

Kalamarides, S. ^{[2
]}

Plat, A. ^{[2
]}

Pfau, G. ^{[3
]}

Fantin, B. ^{[1
]}

机构：

[1] Univ Paris Diderot, Hop Beaujon, AP HP, Serv Med Interne,Sorbonne Paris Cite, F-92110 Clichy, France

[2] Univ Paris Diderot, Hop Beaujon, AP HP, UTAMA,Sorbonne Paris Cite, F-92110 Clichy, France

[3] Assoc Charonne, Dispositif TREND SINTES Paris, F-75012 Paris, France

来源：

REVUE DE MEDECINE INTERNE | 2014年 / 35卷 / 10期

关键词：

Cocaine; Levamisole; Vasculopathy; Neutropenia; CONTAMINATED COCAINE; VASCULOPATHY; NEUTROPENIA;

D O I：

10.1016/j.revmed.2013.10.337

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. - Adulterants are compounds added to street drugs to increase profits for the seller. Levamisole, a veterinary antihelminthic agent, has become the most common adulterant of cocaine. The prevalence of levamisole in samples of cocaine is increasing. Levamisole can lead to neutropenia and to a dramatic vasculopathy and even vasculitis of small and medium-size blood vessels. Case report. - We here reported the first French case of levamisole related toxicity, due to cocaine use in a 50-year-old man, revealed by fever and agranulocytosis, high titters of anti-neutrophil cytoplasmic antibodies (ANCA), anticoagulant and positive Coombs tests. Outcome was slowly favorable with exposition withdrawal. Conclusion. - Clinicians should be aware that agranulocytosis or vasculitis or vasculopathy could be related to levamisole toxicity in individuals who use cocaine. (C) 2013 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：676 / 679

页数：4

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