CoQ10 and Aging

被引：75

作者：

de Barcelos, Isabella Peixoto ^{[1
]}

Haas, Richard H. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92093 USA

[2] Univ Calif San Diego, Dept Pediat, San Diego, CA 92093 USA

来源：

BIOLOGY-BASEL | 2019年 / 8卷 / 02期

关键词：

coenzyme Q10; aging; age-related diseases; mitochondrial dysfunction; COENZYME Q(10) SUPPLEMENTATION; MITOCHONDRIAL ELECTRON-TRANSPORT; RANDOMIZED-CLINICAL-TRIAL; EARLY PARKINSON-DISEASE; OXIDATIVE STRESS; DOUBLE-BLIND; LIFE-SPAN; Q DEFICIENCY; UBIQUINONE BIOSYNTHESIS; COQ(10) DEFICIENCIES;

D O I：

10.3390/biology8020028

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production. Oxidative damage to macromolecules including DNA and electron transport proteins likely increases ROS production resulting in further damage. This oxidative theory of cell aging is supported by the fact that diseases associated with the aging process are marked by increased oxidative stress. Coenzyme Q10 (CoQ(10)) levels fall with aging in the human but this is not seen in all species or all tissues. It is unknown whether lower CoQ(10) levels have a part to play in aging and disease or whether it is an inconsequential cellular response to aging. Despite the current lay public interest in supplementing with CoQ(10), there is currently not enough evidence to recommend CoQ(10) supplementation as an anti-aging anti-oxidant therapy.

引用

页数：22

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