The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

被引：98

作者：

Soldozy, Sauson ^{[1
]}

Norat, Pedro ^{[1
]}

Elsarrag, Mazin ^{[1
]}

Chatrath, Ajay ^{[1
]}

Costello, John S. ^{[1
]}

Sokolowski, Jennifer D. ^{[1
]}

Tvrdik, Petr ^{[1
]}

Kalani, M. Yashar S. ^{[1
]}

Park, Min S. ^{[1
]}

机构：

[1] Univ Virginia Hlth Syst, Dept Neurol Surg, Charlottesville, VA USA

来源：

NEUROSURGICAL FOCUS | 2019年 / 47卷 / 01期

关键词：

cerebral aneurysm; hemodynamics; wall shear stress; computational fluid dynamics; vascular remodeling; COMPUTATIONAL FLUID-DYNAMICS; WALL SHEAR-STRESS; UNRUPTURED INTRACRANIAL ANEURYSMS; COMPLEX HEMODYNAMICS; NATURAL-HISTORY; FLOW CONDITIONS; ASPECT RATIO; RISK-FACTORS; SIZE RATIO; BLOOD-FLOW;

D O I：

10.3171/2019.4.FOCUS19232

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pathogenesis of intracranial aneurysms remains complex and multifactorial. While vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is believed to be induced by hemodynamic forces. Hemodynamic stresses and vascular insults lead to additional aneurysm and vessel remodeling. Advanced imaging techniques allow us to better define the roles of aneurysm and vessel morphology and hemodynamic parameters, such as wall shear stress, oscillatory shear index, and patterns of flow on aneurysm formation, growth, and rupture. While a complete understanding of the interplay between these hemodynamic variables remains elusive, the authors review the efforts that have been made over the past several decades in an attempt to elucidate the physical and biological interactions that govern aneurysm pathophysiology. Furthermore, the current clinical utility of hemodynamics in predicting aneurysm rupture is discussed.

引用

页数：9

共 69 条

[1] Intracranial Aneurysms Occur More Frequently at Bifurcation Sites That Typically Experience Higher Hemodynamic Stresses [J].