Premature B-cell senescence as a consequence of chronic immune activation Implications for vaccination of immune compromised individuals

被引：22

作者：

Palma, Paolo ^{[1
]}

Rinaldi, Stefano ^{[2
]}

Cotugno, Nicola ^{[1
]}

Santilli, Veronica ^{[1
]}

Pahwa, Savita ^{[3
]}

Rossi, Paolo ^{[1
]}

Cagigi, Alberto ^{[1
]}

机构：

[1] Bambino Gesu Pediat Hosp, Unit Immune & Infect Dis, DPUO, Univ Dept Pediat, Rome, Italy

[2] Univ Roma Tor Vergata, Dept Publ Hlth, Chair Pediat, Rome, Italy

[3] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2014年 / 10卷 / 07期

基金：

美国国家卫生研究院;

关键词：

aging; inflammaging; immunosenescence; activation-induced deaminase (AID); double negative B-cells; matureactivated B-cells; predictive biomarkers; immunization; HUMAN BONE-MARROW; IG CLASS SWITCH; HIV-1; INFECTION; INFLUENZA VACCINATION; T-CELLS; MEMORY; EXPRESSION; POPULATION; CD27; RECOMBINATION;

D O I：

10.4161/hv.28698

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this theory by comparing changes occurring to B-cells during healthy aging to the ones occurring during chronic immune activation in younger individuals. Moreover, we discuss how these changes may affect or predict response to vaccination in immune compromised individuals.

引用

页码：2083 / 2088

页数：6