Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants

被引:0
作者
Mofenson, LM
Munderi, P
机构
[1] NICHHD, Adolescent & Maternal AIDS Branch, NIH, Rockville, MD 20852 USA
[2] WHO, CH-1211 Geneva, Switzerland
关键词
toxicity; antiretroviral therapy; perinatal HIV prevention;
D O I
10.1097/01.QAI.0000018366.28828.86
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Worldwide, more than 1600 infants become infected with HIV each day. Almost all infections are a result of rnother-to-child transmission of HIV, with most of these infections occurring in resource-poor countries. In developed Countries, antiret-roviral prophylaxis has dramatically reduced perinatal transmission to <2%. The potential now exists to extend this success to resource-poor countries using effective but shorter and less expensive antiretroviral regimens. With the potential widespread use of antiretroviral therapy for perinatal HIV prevention in resource-limited settings, there will be exposure of increasing numbers of infants to in utero and postpartum antiretroviral drugs for which long-term toxicity data is unknown. This article focuses on a review of what is known about safety of antiretroviral regimens used to interrupt mother-to-child transmission for women and their children.
引用
收藏
页码:200 / 215
页数:16
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