An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl)amides

被引：14
作者：
Londregan, Allyn T. [1 ]
Storer, Gregory [1 ]
Wooten, Ceshea [1 ]
Yang, Xiaojing [1 ]
Warmus, Joseph [1 ]
机构：
[1] Pfizer Global Res & Dev, Groton, CT 06340 USA
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 17期
关键词：
ACID;
D O I：
10.1016/j.tetlet.2009.02.071
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dehydrative amide couplings With 2-pyridylamines suffer from variable yields. A mild and high-yielding synthesis of N-(pyridin-2-yl)amides employing 2-aminopyridine-N-oxides is presented as a solution. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1986 / 1988
页数：3
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