Formation of normal interdigital web spaces in the hand revisited: implications for the pathogenesis of syndactyly in humans and experimental animals

被引：11

作者：

Al-Qattan, M. M. ^{[1
]}

机构：

[1] King Saud Univ, Div Plast Surg, Riyadh 11415, Saudi Arabia

来源：

JOURNAL OF HAND SURGERY-EUROPEAN VOLUME | 2014年 / 39卷 / 05期

关键词：

Inter-digital cell death; apoptosis; web space; hand; syndactyly; PROGRAMMED CELL-DEATH; APICAL ECTODERMAL RIDGE; RETINOIC-ACID; LIMB BUD; MOUSE LIMB; EXPRESSION; APOPTOSIS; MUTATIONS; PATTERNS; GROWTH;

D O I：

10.1177/1753193413491931

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The creation of the normal web spaces has been attributed to apoptosis. This paper presents evidence that lysosomal-mediated cell death and extracellular matrix degradation are important events in addition to cell death by apoptosis. The author proposes the use of the term interdigital cell death-extracellular matrix degradation instead of interdigital apoptosis. Furthermore, the concept of web creation by differential growth is introduced along with the discussion of the latest research in molecular biology and genetics on the topic.

引用

页码：491 / 498

页数：8

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