Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies

被引：68

作者：

Amado, Nathalia G. ^{[1
]}

Predes, Danilo ^{[1
]}

Moreno, Marcela M. ^{[1
]}

Carvalho, Igor O. ^{[1
]}

Mendes, Fabio A. ^{[1
]}

Abreu, Jose G. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biomed Sci, BR-21949590 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 07期

关键词：

beta-catenin; quercetin; colorectal cancer; isoquercitrin; polyphenols; small molecules; SMALL-MOLECULE INHIBITORS; CHEMICAL GENETIC SCREEN; COLON-CARCINOMA CELLS; BETA-CATENIN; NATURAL-PRODUCTS; APC(MIN/+) MICE; DRUG DISCOVERY; WNT INHIBITOR; TUMOR-GROWTH; LUNG-CANCER;

D O I：

10.3390/ijms150712094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well documented that natural products have played an important role in anticancer therapy. Many studies focus on the ability of these natural compounds to modulate tumor-related signaling pathways and the relationship of these properties to an anticancer effect. According to the World Health Organization (WHO), colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death among men and women. Therefore, finding strategies to fight against CRC is an emergent health problem. CRC has a strong association with deregulation of Wnt/beta-catenin signaling pathway. As some types of natural compounds are capable of modulating the Wnt/beta-catenin signaling, one important question is whether they could counteract CRC. In this review, we discuss the role of flavonoids, a class of natural compounds, on Wnt/beta-catenin regulation and its possible potential for therapeutic usage on colorectal cancer.

引用

页码：12094 / 12106

页数：13

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