Flavonoids and Wnt/β-Catenin Signaling: Potential Role in Colorectal Cancer Therapies

被引：68
作者：
Amado, Nathalia G. [1 ]
Predes, Danilo [1 ]
Moreno, Marcela M. [1 ]
Carvalho, Igor O. [1 ]
Mendes, Fabio A. [1 ]
Abreu, Jose G. [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Inst Biomed Sci, BR-21949590 Rio De Janeiro, Brazil
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 07期
关键词：
beta-catenin; quercetin; colorectal cancer; isoquercitrin; polyphenols; small molecules; SMALL-MOLECULE INHIBITORS; CHEMICAL GENETIC SCREEN; COLON-CARCINOMA CELLS; BETA-CATENIN; NATURAL-PRODUCTS; APC(MIN/+) MICE; DRUG DISCOVERY; WNT INHIBITOR; TUMOR-GROWTH; LUNG-CANCER;
D O I：
10.3390/ijms150712094
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is now well documented that natural products have played an important role in anticancer therapy. Many studies focus on the ability of these natural compounds to modulate tumor-related signaling pathways and the relationship of these properties to an anticancer effect. According to the World Health Organization (WHO), colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death among men and women. Therefore, finding strategies to fight against CRC is an emergent health problem. CRC has a strong association with deregulation of Wnt/beta-catenin signaling pathway. As some types of natural compounds are capable of modulating the Wnt/beta-catenin signaling, one important question is whether they could counteract CRC. In this review, we discuss the role of flavonoids, a class of natural compounds, on Wnt/beta-catenin regulation and its possible potential for therapeutic usage on colorectal cancer.
引用
收藏
页码：12094 / 12106
页数：13
相关论文
共 81 条
  • [1] Molecular targets of dietary agents for prevention and therapy of cancer
    Aggarwal, BB
    Shishodia, S
    [J]. BIOCHEMICAL PHARMACOLOGY, 2006, 71 (10) : 1397 - 1421
  • [2] Amado NG, 2012, CURR TOP MED CHEM, V12, P2103
  • [3] Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer
    Amado, Nathalia G.
    Fonseca, Barbara F.
    Cerqueira, Debora M.
    Neto, Vivaldo Moura
    Abreu, Jose G.
    [J]. LIFE SCIENCES, 2011, 89 (15-16) : 545 - 554
  • [4] Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes β-catenin cellular localization
    Amado, Nathalia G.
    Cerqueira, Debora M.
    Menezes, Fabio S.
    Mendes da Silva, Joaquim Fernando
    Neto, Vivaldo Moura
    Abreu, Jose G.
    [J]. ANTI-CANCER DRUGS, 2009, 20 (07) : 543 - 552
  • [5] [Anonymous], 2010, GLOBOCAN 2008 V1 2 C
  • [6] Diagnostic value of symptoms for colorectal cancer in primary care: a systematic review
    Hamilton, William
    Astin, Margaret
    Griffin, Tom
    Neal, Richard D.
    Rose, Peter
    [J]. BRITISH JOURNAL OF GENERAL PRACTICE, 2011, 61 (586) : e231 - e243
  • [7] Efficacy of selected natural products as therapeutic agents against cancer
    Banerjee, Sanjeev
    Wang, Zhiwei
    Mohammad, Mussop
    Sarkar, Faziui H.
    Mohammad, Ramzi M.
    [J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (03): : 492 - 496
  • [8] Inhibition Of Tumorigenesis in ApcMin/+ Mice by a Combination of (-)-Epigallocatechin-3-gallate and Fish Oil
    Bose, Mousumi
    Hao, Xingpei
    Ju, Jihyeung
    Husain, Ali
    Park, Sunny
    Lambert, Joshua D.
    Yang, Chung S.
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (19) : 7695 - 7700
  • [9] Lessons from natural molecules
    Clardy, J
    Walsh, C
    [J]. NATURE, 2004, 432 (7019) : 829 - 837
  • [10] Cancer Prevention With Natural Compounds
    Collett, Norleena P.
    Amin, A. R. M. Ruhul
    Bayraktar, Soley
    Pezzuto, John M.
    Shin, Dong M.
    Khuri, Fadlo R.
    Aggarwal, Bharat B.
    Surh, Young-Joon
    Kucuk, Omer
    [J]. SEMINARS IN ONCOLOGY, 2010, 37 (03) : 258 - 281
123456789