Plasticity of bone marrow-derived stem cells

被引：307

作者：

Grove, JE ^{[1
]}

Bruscia, E ^{[1
]}

Krause, DS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USA

来源：

STEM CELLS | 2004年 / 22卷 / 04期

关键词：

adult stem cell; hematopoiesis; plasticity;

D O I：

10.1634/stemcells.22-4-487

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cell plasticity refers to the ability of adult stem cells to acquire mature phenotypes that are different from their tissue of origin. Adult bone marrow cells (BMCs) include two populations of bone marrow stem cells (BMCs): hematopoietic stem cells (HSCs), which give rise to all mature lineages of blood, and mesenchymal stem cells (MSCs), which can differentiate into bone, cartilage, and fat. In this article, we review the literature that lends credibility to the theory that highly plastic BMCs have a role in maintenance and repair of nonhematopoietic tissue. We discuss the possible mechanisms by which this may occur. Also reviewed is the possibility that adult BMCs can change their gene expression profile after fusion with a mature cell, which has brought into question whether this stem cell plasticity is real.

引用

页码：487 / 500

页数：14

共 110 条

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