Wnt/PCP signaling:: A veritable polar star in establishing patterns of polarity in embryonic tissues

被引：69
作者：
Barrow, Jeffery R. [1 ]
机构：
[1] Brigham Young Univ, Dept Physiol & Dev Biol, Provo, UT 84602 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 02期
关键词：
Wnt/planar cell polarity; embryonic patterning; vertebrate;
D O I：
10.1016/j.semcdb.2006.04.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Embryonic patterning has traditionally been viewed as the establishment of spatially significant gene expression in response to secreted signals. Recent work has highlighted the role of the Wnt/planar cell polarity (PCP) pathway in patterning tissues. Rather than establishing characteristic arrays of gene expression, however, this pathway functions to institute uniform polarity of cells within a tissue. Cells thus polarized can undergo directed migrations, cell divisions, etc., which are essential for normal morphogenesis. In this review, I will highlight the similarities between mechanisms that establish patterns of polarity between Drosophila and vertebrates. Further, I will discuss recent advances with regard to Wnt/PCP signaling in vertebrates. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：185 / 193
页数：9
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