Recent Developments in C-H functionalisation of Benzofurans and Benzothiophenes

被引：21

作者：

Morgan, David ^{[1
]}

Yarwood, Stephen J. ^{[2
]}

Barker, Graeme ^{[1
]}

机构：

[1] Heriot Watt Univ, Inst Chem Sci, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Heriot Watt Univ, Inst Biol Chem Biophys & Bioengn, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

Benzofuran; Benzothiophene; Functionalization; Heterocycles; Synthetic methods; BOND ARYLATIONS; ARENES; HETEROARYLATION; CONSTRUCTION; THIOLATION;

D O I：

10.1002/ejoc.202001470

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzofurans and benzothiophenes are important pharmaceutical motifs, appearing in a broad range of small molecule therapeutic classes. Often overlooked by synthetic methodologists in favour reactions of the analogous indole bicyclic system, there is nevertheless a plurality of approaches to effecting benzofuran and benzothiophene C-H functionalisations. In this review, we summarise progress in this area over the past five years, including 1) alkylations, 2) arylations and heteroarylations, 3) carboxylations, carbamoylations, and C-heteroatom bond formations and 4) cyclisations.

引用

页码：1072 / 1102

页数：31

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