The clinical relevance of the microbiome when managing paediatric infectious diseases-Narrative review

被引：2
作者：
Sainz, Talia [1 ,2 ,3 ]
Delgado, Jaime [1 ,2 ,3 ]
Mendez-Echevarria, Ana [1 ,2 ,3 ]
Santiago, Begona [3 ,4 ,5 ]
Lopez-Varela, Elisa [6 ]
Aguilera-Alonso, David [3 ,4 ,5 ]
Saavedra-Lozano, Jesus [3 ,4 ,5 ]
Rodriguez-Fernandez, Rosa [3 ,4 ,5 ]
Holguin, Africa [3 ,7 ]
Navarro, Marisa L. [3 ,4 ,5 ]
Munoz-Fernandez, Maria Angeles [3 ,4 ,5 ]
Rivero-Calle, Irene [3 ,8 ,9 ]
Solana, Maria Jose [3 ,4 ,5 ]
Lopez-Herce, Jesus [3 ,4 ,5 ]
Calvo, Cristina [1 ,2 ,3 ]
机构：
[1] Hosp La Paz, Madrid, Spain
[2] La Paz Res Intitute IdiPAZ, Madrid, Spain
[3] Traslat Res Network Pediat Infect Dis RITIP, Madrid, Spain
[4] Hosp Gen Univ Gregorio Maranon, Madrid, Spain
[5] Res Inst IISGM, Madrid, Spain
[6] Univ Barcelona, Hosp Clin, Barcelona Ctr Int Hlth Res, ISGlobal, Barcelona, Spain
[7] Hosp Ramon & Cajal, CIBERESP, Ramon y Cajal Res Inst IRyCIS, Madrid, Spain
[8] Hosp Clin Univ Santiago CHUS, Santiago De Compostela, Spain
[9] Hlth Res Inst Santiago de Compostela IDIS, Santiago De Compostela, Spain
来源：
ACTA PAEDIATRICA | 2021年 / 110卷 / 02期
关键词：
children; infectious diseases; microbiota; microbiome; pre‐ and probiotics; NASOPHARYNGEAL MICROBIOTA; CHILDREN; HOST; RESPONSES; HIV;
D O I：
10.1111/apa.15578
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge. Aims This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children. Methods We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome-related knowledge for translation to clinical practice. Results and Conclusion The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so-called microbiome thinking into our routine clinical practice.
引用
收藏
页码：441 / 449
页数：9
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