Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo

被引：16

作者：

Wu, Peng ^{[1
,2
]}

Song, Ziteng ^{[1
,2
]}

Li, Ying ^{[1
,2
]}

Wang, Huimei ^{[1
,2
]}

Zhang, Han ^{[1
,2
]}

Bao, Jiahe ^{[1
,2
]}

Li, Yuhao ^{[3
]}

Cui, Jianlin ^{[3
]}

Jin, Da-Qing ^{[3
]}

Wang, Aijie ^{[4
,5
]}

Liang, Bin ^{[5
]}

Lee, Dongho ^{[6
]}

Xu, Jing ^{[1
,2
]}

Guo, Yuanqiang ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300050, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300050, Peoples R China

[3] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

[4] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, Beijing 100085, Peoples R China

[5] Harbin Inst Technol Shenzhen, Sch Civil & Environm Engn, Shenzhen 518055, Peoples R China

[6] Korea Univ, Coll Life Sci & Biotechnol, Dept Biosyst & Biotechnol, Seoul 136713, South Korea

来源：

BIOORGANIC CHEMISTRY | 2020年 / 104卷

基金：

中国国家自然科学基金;

关键词：

Iridoids; Anti-inflammatory potency; NO inhibition; Zebrafish model; Patrinia heterophylla; ANTI-NEUROINFLAMMATORY AGENTS; ROOTS; INHIBITORS; VALEPOTRIATE; EXPRESSION; ANTITUMOR; RHIZOMES; PATHWAY; DEATH; PLANT;

D O I：

10.1016/j.bioorg.2020.104331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation, especially chronic inflammation, has been found to be closely related to the pathology of many diseases and the discovery of bioactive natural products to inhibit NO production is one of strategies to treat inflammation. In our continuous search for bioactive natural substances as potential anti-inflammatory agents, five new compounds (1-5) were extracted and purified from Patrinia heterophylla. The NMR and MS data analysis, along with electronic circular dichroism (ECD) calculations, led to the identification of these isolates, which were new iridoids. Using cell and zebrafish models, the in vitro and in vivo anti-inflammatory effects were conducted to evaluate the potency of anti-inflammation of these compounds. The preliminary mechanism was explored using molecular docking and Western blotting experiments.

引用

页数：9

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