Periodontal pathogens participate in synovitis in patients with rheumatoid arthritis in clinical remission: a retrospective case-control study

被引:15
|
作者
Kimura, Yuko [1 ]
Yoshida, Shuzo [1 ]
Takeuchi, Tohru [1 ]
Kimura, Motoshi [2 ]
Yoshikawa, Ayaka [1 ]
Hiramatsu, Yuri [1 ]
Ishida, Takaaki [1 ]
Makino, Shigeki [1 ]
Takasugi, Yoshihiro [3 ]
Hanafusa, Toshiaki [1 ]
机构
[1] Osaka Med Coll, Dept Internal Med 1, Takatsuki, Osaka 5698686, Japan
[2] Osaka Med Coll, Dept Hyg & Publ Hlth, Div Prevent & Social Med, Takatsuki, Osaka 5698686, Japan
[3] Kinki Univ, Fac Med, Dept Anesthesiol, Higashiosaka, Osaka 577, Japan
关键词
rheumatoid arthritis; periodontitis; ultrasonography; power Doppler; clinical remission; periodontal pathogen; DISEASE-ACTIVITY; RADIOGRAPHIC PROGRESSION; PORPHYROMONAS-GINGIVALIS; GENE POLYMORPHISMS; BONE EROSIONS; BACTERIAL-DNA; ULTRASONOGRAPHY; ASSOCIATION; ULTRASOUND; FINGER;
D O I
10.1093/rheumatology/kev274
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The objective of this study was to investigate the role of periodontal pathogens in RA in remission. Methods. Twenty-one patients with active RA and 70 patients in clinical remission, including 48 patients with synovitis [US power Doppler (USPD)(+) group] and 22 patients without synovitis [USPD(-) group] were clinically assessed by US. CRP, ESR, haemoglobin, MMP-3, RF and ACPA were measured. Antibody titres against four types of periodontal pathogen [Aggregatibacter actinomycetemcomitans, Eikenella corrodens (Ec), Porphyromonas gingivalis and Prevotella intermedia (Pi)] were analysed using ELISA. Results. Musculoskeletal US examination showed that 68.6% of patients with RA in clinical remission exhibited synovitis. CRP, ESR, haemoglobin, MMP-3 and RF levels in both the USPD(+) and USPD(-) groups were clearly lower compared with the RA group in non-remission. The IgG serum antibody titre against Ec in the non-remission RA(+) group was significantly greater than that in the USPD(+) group, and the IgG antibody titre against Pi in the non-remission RA and USPD(+) groups was greater than in the USPD(-) group. Conclusion. More than half of RA patients in remission showed persistent synovitis. This synovitis may be associated with periodontal disease-causing Pi. Thus, treating periodontal disease should also be considered in order to achieve more profound remission of RA.
引用
收藏
页码:2257 / 2263
页数:7
相关论文
共 50 条
  • [21] Predictive value of bone destruction and duration of clinical remission for subclinical synovitis in rheumatoid arthritis patients
    Tokai, Nao
    Ogasawara, Michihiro
    Gorai, Misa
    Matsuki, Yuko
    Yamada, Yusuke
    Murayama, Go
    Sugisaki, Nagachika
    Nemoto, Takuya
    Ando, Seiichiro
    Minowa, Kentaro
    Kon, Takayuki
    Tada, Kurisu
    Matsushita, Masakazu
    Yamaji, Ken
    Tamura, Naoto
    Makino, Shigeki
    Takasaki, Yoshinari
    MODERN RHEUMATOLOGY, 2015, 25 (04) : 540 - 545
  • [22] Ultrasound remission in patients with rheumatoid arthritis in clinical remission
    Fakhfakh, Rym
    Elamri, Nejla
    Baccouche, Khadija
    Laataoui, Sadok
    Zeglaoui, Hela
    Bouajina, Elyes
    REUMATOLOGIA, 2021, 59 (06): : 378 - 385
  • [23] Pneumocystis jiroveci Pneumonia in Patients With Rheumatoid Arthritis Treated With Infliximab: A Retrospective Review and Case-Control Study of 21 Patients
    Komano, Yukiko
    Harigai, Masayoshi
    Koike, Ryuji
    Sugiyama, Haruhito
    Ogawa, Jun
    Saito, Kazuyoshi
    Sekiguchi, Naoya
    Inoo, Masayuki
    Onishi, Ikuko
    Ohashi, Hiroyuki
    Amamoto, Fujio
    Miyata, Masayuki
    Ohtsubo, Hideo
    Hiramatsu, Kazuko
    Iwamoto, Masahiro
    Minota, Seiji
    Matsuoka, Naoki
    Kageyama, Goichi
    Imaizumi, Kazuyoshi
    Tokuda, Hitoshi
    Okochi, Yasumi
    Kudo, Koichiro
    Tanaka, Yoshiya
    Takeuchi, Tsutomu
    Miyasaka, Nobuyuki
    ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2009, 61 (03): : 305 - 312
  • [24] MRI REMISSION IN PATIENTS WITH RHEUMATOID ARTHRITIS IN CLINICAL REMISSION
    Cosso, C.
    Barbieri, F.
    Zampogna, G.
    Paparo, F.
    Aleo, E.
    Pizzorni, C.
    Garlaschi, G.
    Cutolo, M.
    Cimmino, M. A.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 : 750 - 750
  • [25] ACTIVE SYNOVITIS IN RHEUMATOID ARTHRITIS PATIENTS WHILE BEING ON SDAI REMISSION
    Opris, D.
    Borangiu, A.
    Gudu, T.
    Saulescu, I.
    Groseanu, L.
    Predeteanu, D.
    Balanescu, A.
    Ionescu, R.
    ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 672 - 672
  • [26] Pain score as a predictor of subsequent fragility fracture in postmenopausal patients with rheumatoid arthritis: A retrospective case-control study
    Yoshii, Ichiro
    Sawada, Naoya
    Chijiwa, Tatsumi
    OSTEOPOROSIS AND SARCOPENIA, 2023, 9 (04) : 150 - 156
  • [27] Rheumatoid arthritis and periodontitis: a Jordanian case-control study
    Rola Alhabashneh
    Khaldoon Alawneh
    Raed Alshami
    Kamal Al Naji
    Journal of Public Health, 2020, 28 : 547 - 554
  • [28] Rheumatoid arthritis and periodontitis: a Jordanian case-control study
    Alhabashneh, Rola
    Alawneh, Khaldoon
    Alshami, Raed
    Al Naji, Kamal
    JOURNAL OF PUBLIC HEALTH-HEIDELBERG, 2020, 28 (05): : 547 - 554
  • [29] Exercise Echocardiography in Rheumatoid Arthritis: A Case-Control Study
    Saghir, Mohammed K.
    Jost, Christine Attenhofer
    Warrington, Kenneth J.
    Cha, Stephen S.
    Pellikka, Patricia A.
    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2009, 22 (11) : 1228 - 1231
  • [30] A CASE-CONTROL STUDY OF RHEUMATOID-ARTHRITIS IN LEBANON
    DARWISH, MJ
    ARMENIAN, HK
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1987, 16 (03) : 420 - 424