Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice

被引：41

作者：

Xie, Zhenxing ^{[1
]}

Xia, Shufang ^{[1
]}

Le, Guo-Wei ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2014年 / 8卷

关键词：

Obesity; Oxidative stress; Hypothyroidism; Thyroid stimulating hormone; Thyroid hormone; METABOLIC SYNDROME; IODOTHYRONINE DEIODINASES; MESSENGER-RNA; EXPRESSION; HORMONE; OBESITY; CELLS; NRF2; ACTIVATION; GENES;

D O I：

10.1016/j.jff.2014.03.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Redox status and thyroid functions of diet-induced obesity (DIO) and DIO-resistant (DIO-R) mice from 20-week high-fat diet-fed (HFD) mice were studied (study I). Whether anti-obesity action of gamma-aminobutyric acid (GABA) in HFD mice was related to its antioxidative action or improvement in thyroid function was also examined (study II) by GABA in drinking water (0.2, 0.12 and 0.06%). In DIO mice, thyroid stimulating hormone (TSH) remarkably increased, free thyroid hormones (THs) decreased, thyroid structures deformed and expressions of THs synthesis-specific and thyroid antioxidalive markers, THs receptors beta and deiodinases in hypothalamus and liver decreased. DIO-R mice showed normalized TSH, increased THs and its functions. Three GABA treatments normalized TSH, while 0.2% and 0.12% GABA treatments restored redox status, raised THs excretions and functions. Consequently, Down-regulated thyroid and THs functions in DIO mice accounted for obesity. GABA could prevent obesity by ameliorating oxidative stress and HFD-disrupted functions of thyroid and THs. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：76 / 86

页数：11

共 52 条

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