Anti-Mullerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development

被引：52
作者：
Johansen, Marie Lindhardt [1 ]
Hagen, Casper P. [1 ]
Johannsen, Trine Holm [1 ]
Main, Katharina M. [1 ]
Picard, Jean-Yves [2 ,3 ]
Jorgensen, Anne [1 ]
Rajpert-De Meyts, Ewa [1 ]
Juul, Anders [1 ]
机构：
[1] Univ Copenhagen, Fac Med & Hlth Sci, Rigshosp 5064, Dept Growth & Reprod,GR, DK-2100 Copenhagen, Denmark
[2] INSERM, Res Unit, U782, F-92140 Clamart, France
[3] Univ Paris 11, F-92140 Clamart, France
来源：
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2013年 / 2013卷
关键词：
GRANULOSA-CELL TUMOR; POLYCYSTIC-OVARY-SYNDROME; INHIBITING SUBSTANCE; ANTIMULLERIAN HORMONE; SERUM-LEVELS; HYPOGONADOTROPIC HYPOGONADISM; TURNER SYNDROME; KLINEFELTER-SYNDROME; EXPRESSION PATTERN; FOLLICLE COUNT;
D O I：
10.1155/2013/198698
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Using measurements of circulating anti-Mullerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age-and sex-specific reference ranges for the Immunotech assay and conversion factors for the DSL and Generation II assays. With this tool in hand, the pediatrician can use serum concentrations of AMH when determining the presence of testicular tissue in patients with bilaterally absent testes or more severe Disorders of Sex Development (DSD). Furthermore, AMH can be used as a marker of premature ovarian insufficiency (POI) in both Turner Syndrome patients and in girls with cancer after treatment with alkylating gonadotoxic agents. Lastly, its usefulness has been proposed in the diagnosis of polycystic ovarian syndrome (PCOS) and ovarian granulosa cell tumors and in the evaluation of patients with hypogonadotropic hypogonadism.
引用
收藏
页数：10
相关论文
共 106 条
  • [31] Mullerian-inhibiting substance inhibits cytochrome P450 aromatase activity in human granulosa lutein cell culture
    Grossman, Michael P.
    Nakajima, Steven T.
    Fallat, Mary E.
    Siow, Yong
    [J]. FERTILITY AND STERILITY, 2008, 89 : 1364 - 1370
  • [32] THE PERSISTENT MULLERIAN DUCT SYNDROME - A MOLECULAR APPROACH
    GUERRIER, D
    TRAN, D
    VANDERWINDEN, JM
    HIDEUX, S
    VANOUTRYVE, L
    LEGEAI, L
    BOUCHARD, M
    VANVLIET, G
    DELAET, MH
    PICARD, JY
    KAHN, A
    JOSSO, N
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (01) : 46 - 52
  • [33] Anti-Mullerian hormone levels in serum from human foetuses and children:: pattern and clinical interest
    Guibourdenche, J
    Lucidarme, N
    Chevenne, D
    Rigal, O
    Nicolas, M
    Luton, D
    Léger, J
    Porquet, D
    Noël, M
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2003, 211 (1-2) : 55 - 63
  • [34] MULLERIAN INHIBITING SUBSTANCE AS A MARKER FOR OVARIAN SEX-CORD TUMOR
    GUSTAFSON, ML
    LEE, MM
    SCULLY, RE
    MONCURE, AC
    HIRAKAWA, T
    GOODMAN, A
    MUNTZ, HG
    DONAHOE, PK
    MACLAUGHLIN, DT
    FULLER, AF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (07) : 466 - 471
  • [35] MULLERIAN INHIBITING SUBSTANCE IN THE DIAGNOSIS AND MANAGEMENT OF INTERSEX AND GONADAL ABNORMALITIES
    GUSTAFSON, ML
    LEE, MM
    ASMUNDSON, L
    MACLAUGHLIN, DT
    DONAHOE, PK
    [J]. JOURNAL OF PEDIATRIC SURGERY, 1993, 28 (03) : 439 - 444
  • [36] Hagen Casper P, 2011, Pediatr Endocrinol Rev, V9 Suppl 1, P525
  • [37] Serum levels of antimullerian hormone in early maturing girls before, during, and after suppression with GnRH agonist
    Hagen, Casper P.
    Sorensen, Kaspar
    Anderson, Richard A.
    Juul, Anders
    [J]. FERTILITY AND STERILITY, 2012, 98 (05) : 1326 - 1330
  • [38] Individual serum levels of anti-Mullerian hormone in healthy girls persist through childhood and adolescence: a longitudinal cohort study
    Hagen, Casper P.
    Aksglaede, Lise
    Sorensen, Kaspar
    Mouritsen, Annette
    Andersson, Anna-Maria
    Petersen, Jorgen Holm
    Main, Katharina M.
    Juul, Anders
    [J]. HUMAN REPRODUCTION, 2012, 27 (03) : 861 - 866
  • [39] FSH, LH, inhibin B and estradiol levels in Turner syndrome depend on age and karyotype: longitudinal study of 70 Turner girls with or without spontaneous puberty
    Hagen, Casper P.
    Main, Katharina M.
    Kjaergaard, Susanne
    Juul, Anders
    [J]. HUMAN REPRODUCTION, 2010, 25 (12) : 3134 - 3141
  • [40] Serum Levels of Anti-Mullerian Hormone as a Marker of Ovarian Function in 926 Healthy Females from Birth to Adulthood and in 172 Turner Syndrome Patients
    Hagen, Casper P.
    Aksglaede, Lise
    Sorensen, Kaspar
    Main, Katharina M.
    Boas, Malene
    Cleemann, Line
    Holm, Kirsten
    Gravholt, Claus H.
    Andersson, Anna-Maria
    Pedersen, Anette T.
    Petersen, Jorgen Holm
    Linneberg, Allan
    Kjaergaard, Susanne
    Juul, Anders
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (11) : 5003 - 5010
12345678910