The rise of pericytes in neurovascular research

被引:14
作者
Beard, Daniel J. [1 ,2 ]
Brown, Lachlan S. [3 ]
Sutherland, Brad A. [3 ]
机构
[1] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia
[2] Univ Oxford, Radcliffe Dept Med, Acute Stroke Programme, Oxford, England
[3] Univ Tasmania, Tasmanian Sch Med, Coll Hlth & Med, Hobart, Tas, Australia
基金
英国医学研究理事会;
关键词
Pericytes; brain; blood-brain barrier; cerebral blood flow; Alzheimer's disease; stroke; BLOOD-FLOW; BRAIN; CELLS; CONTRACTILITY; PHENOTYPE; HEALTH; LEADS;
D O I
10.1177/0271678X20958497
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The popularity of pericyte research is increasing, and this was not more evident than at the recent 2019 Brain meeting in Yokohama which featured a large number of presentations focused on brain pericyte research, including the Presidential Symposium. In this article, we will provide a history of brain pericyte research, present the results of our analysis showing a substantial increase in brain pericyte research presented at Brain meetings since 2005, suggest reasons for their increased popularity, and comment on what the future holds for brain pericyte research.
引用
收藏
页码:2366 / 2373
页数:8
相关论文
共 55 条
[31]   APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline [J].
Montagne, Axel ;
Nation, Daniel A. ;
Sagare, Abhay P. ;
Barisano, Giuseppe ;
Sweeney, Melanie D. ;
Chakhoyan, Ararat ;
Pachicano, Maricarmen ;
Joe, Elizabeth ;
Nelson, Amy R. ;
D'Orazio, Lina M. ;
Buennagel, David P. ;
Harrington, Michael G. ;
Benzinger, Tammie L. S. ;
Fagan, Anne M. ;
Ringman, John M. ;
Schneider, Lon S. ;
Morris, John C. ;
Reiman, Eric M. ;
Caselli, Richard J. ;
Chui, Helena C. ;
TCW, Julia ;
Chen, Yining ;
Pa, Judy ;
Conti, Peter S. ;
Law, Meng ;
Toga, Arthur W. ;
Zlokovic, Berislav V. .
NATURE, 2020, 581 (7806) :70-+
[32]   Skeletal and cardiac muscle pericytes: Functions and therapeutic potential [J].
Murray, Iain R. ;
Baily, James E. ;
Chen, William C. W. ;
Dar, Ayelet ;
Gonzalez, Zaniah N. ;
Jensen, Andrew R. ;
Petrigliano, Frank A. ;
Deb, Arjun ;
Henderson, Neil C. .
PHARMACOLOGY & THERAPEUTICS, 2017, 171 :65-74
[33]   Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction [J].
Nation, Daniel A. ;
Sweeney, Melanie D. ;
Montagne, Axel ;
Sagare, Abhay P. ;
D'Orazio, Lina M. ;
Pachicano, Maricarmen ;
Sepehrband, Farshid ;
Nelson, Amy R. ;
Buennagel, David P. ;
Harrington, Michael G. ;
Benzinger, Tammie L. S. ;
Fagan, Anne M. ;
Ringman, John M. ;
Schneider, Lon S. ;
Morris, John C. ;
Chui, Helena C. ;
Law, Meng ;
Toga, Arthur W. ;
Zlokovic, Berislav V. .
NATURE MEDICINE, 2019, 25 (02) :270-+
[34]   Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brainin vivo [J].
Nelson, Amy R. ;
Sagare, Meghana A. ;
Wang, Yaoming ;
Kisler, Kassandra ;
Zhao, Zhen ;
Zlokovic, Berislav V. .
FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
[35]   Novel method to study pericyte contractility and responses to ischaemia invitro using electrical impedance [J].
Neuhaus, Ain A. ;
Couch, Yvonne ;
Sutherland, Brad A. ;
Buchan, Alastair M. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, 37 (06) :2013-2024
[36]   Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss [J].
Nikolakopoulou, Angeliki M. ;
Montagne, Axel ;
Kisler, Kassandra ;
Dai, Zhonghua ;
Wang, Yaoming ;
Huuskonen, Mikko T. ;
Sagare, Abhay P. ;
Lazic, Divna ;
Sweeney, Melanie D. ;
Kong, Pan ;
Wang, Min ;
Owens, Nelly Chuqui ;
Lawson, Erica J. ;
Xie, Xiaochun ;
Zhao, Zhen ;
Zlokovic, Berislav, V .
NATURE NEUROSCIENCE, 2019, 22 (07) :1089-+
[37]   Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes [J].
Nortley, Ross ;
Korte, Nils ;
Izquierdo, Pablo ;
Hirunpattarasilp, Chanawee ;
Mishra, Anusha ;
Jaunmuktane, Zane ;
Kyrargyri, Vasiliki ;
Pfeiffer, Thomas ;
Khennouf, Lila ;
Madry, Christian ;
Gong, Hui ;
Richard-Loendt, Angela ;
Huang, Wenhui ;
Saito, Takashi ;
Saido, Takaomi C. ;
Brandner, Sebastian ;
Sethi, Huma ;
Attwell, David .
SCIENCE, 2019, 365 (6450) :250-+
[38]   Brain pericytes acquire a microglial phenotype after stroke [J].
Ozen, Ilknur ;
Deierborg, Tomas ;
Miharada, Kenichi ;
Padel, Thomas ;
Englund, Elisabet ;
Genove, Guillem ;
Paul, Gesine .
ACTA NEUROPATHOLOGICA, 2014, 128 (03) :381-396
[39]   Bidirectional control of CNS capillary diameter by pericytes [J].
Peppiatt, Claire M. ;
Howarth, Clare ;
Mobbs, Peter ;
Attwell, David .
NATURE, 2006, 443 (7112) :700-704
[40]   Pericytes support neutrophil transmigration via interleukin-8 across a porcine co-culture model of the blood-brain barrier [J].
Pieper, Christian ;
Pieloch, Paulina ;
Galla, Hans-Joachim .
BRAIN RESEARCH, 2013, 1524 :1-11