Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

被引：1267
作者：
Morel, Anne-Pierre [1 ]
Lievre, Marjory [1 ]
Thomas, Clemence [1 ,2 ]
Hinkal, George [1 ,2 ]
Ansieau, Stephane [1 ,2 ]
Puisieux, Alain [1 ,2 ,3 ]
机构：
[1] Ctr Leon Berard, F-69373 Lyon, France
[2] Inserm, U590, Lyon, France
[3] Univ Lyon, ISPB, Lyon, France
来源：
PLOS ONE | 2008年 / 3卷 / 08期
关键词：
D O I：
10.1371/journal.pone.0002888
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells'' in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells'' can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.
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页数：7
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