Direct and crossed effects of somatosensory electrical stimulation on motor learning and neuronal plasticity in humans

被引:31
作者
Veldman, M. P. [1 ]
Zijdewind, I. [2 ]
Solnik, S. [3 ,4 ]
Maffiuletti, N. A. [5 ]
Berghuis, K. M. M. [1 ]
Javet, M. [6 ]
Negyesi, J. [7 ]
Hortobagyi, T. [1 ,8 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Ctr Human Movement Sci, NL-9713 AV Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 AV Groningen, Netherlands
[3] Penn State Univ, Dept Kinesiol, Motor Control Lab, State Coll, PA USA
[4] Univ Sch Phys Educ, Wroclaw, Poland
[5] Schulthess Clin, Neuromuscular Res Lab, Zurich, Switzerland
[6] ETH, Dept Hlth Sci & Technol, Zurich, Switzerland
[7] Univ Phys Educ, Dept Biomech Kinesiol & Informat, Budapest, Hungary
[8] Northumbria Univ, Fac Hlth & Life Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England
关键词
Corticospinal excitability; Interlimb transfer; Motor evoked potential; Primary motor cortex; Transcranial magnetic stimulation; PERIPHERAL-NERVE STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; INTERVAL INTRACORTICAL INHIBITION; PAIRED ASSOCIATIVE STIMULATION; USE-DEPENDENT PLASTICITY; CORTEX EXCITABILITY; CORTICOMOTOR EXCITABILITY; CHRONIC STROKE; MEDIAN NERVE; INTERHEMISPHERIC INHIBITION;
D O I
10.1007/s00421-015-3248-z
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Purpose Sensory input can modify voluntary motor function. We examined whether somatosensory electrical stimulation (SES) added to motor practice (MP) could augment motor learning, interlimb transfer, and whether physiological changes in neuronal excitability underlie these changes. Methods Participants (18-30 years, n = 31) received MP, SES, MP + SES, or a control intervention. Visuomotor practice included 300 trials for 25 min with the right-dominant wrist and SES consisted of weak electrical stimulation of the radial and median nerves above the elbow. Single-and double-pulse transcranial magnetic stimulation (TMS) metrics were measured in the intervention and nonintervention extensor carpi radialis. Results There was 27 % motor learning and 9 % (both p < 0.001) interlimb transfer in all groups but SES added to MP did not augment learning and transfer. Corticospinal excitability increased after MP and SES when measured at rest but it increased after MP and decreased after SES when measured during contraction. No changes occurred in intra-cortical inhibition and facilitation. MP did not affect the TMS metrics in the transfer hand. In contrast, corticospinal excitability strongly increased after SES with MP + SES showing sharply opposite of these effects. Conclusion Motor practice and SES each can produce motor learning and interlimb transfer and are likely to be mediated by different mechanisms. The results provide insight into the physiological mechanisms underlying the effects of MP and SES on motor learning and cortical plasticity and show that these mechanisms are likely to be different for the trained and stimulated motor cortex and the non-trained and non-stimulated motor cortex.
引用
收藏
页码:2505 / 2519
页数:15
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