The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity

被引：95

作者：

Carhart-Harris, Robin L. ^{[1
]}

Murphy, Kevin ^{[8
]}

Leech, Robert ^{[2
]}

Erritzoe, David ^{[1
]}

Wall, Matthew B. ^{[4
,6
]}

Ferguson, Bart ^{[5
]}

Williams, Luke T. J. ^{[1
]}

Roseman, Leor ^{[1
]}

Brugger, Stefan ^{[1
]}

De Meer, Ineke ^{[6
]}

Tanner, Mark ^{[6
]}

Tyacke, Robin ^{[1
]}

Wolff, Kim ^{[9
]}

Sethi, Ajun ^{[1
]}

Bloomfield, Michael A. P. ^{[3
]}

Williams, Tim M. ^{[1
]}

Bolstridge, Mark ^{[1
]}

Stewart, Lorna ^{[5
]}

Morgan, Celia ^{[5
]}

Newbould, Rexford D. ^{[6
]}

Feilding, Amanda ^{[7
]}

Curran, H. Val ^{[5
]}

Nutt, David J. ^{[1
]}

机构：

[1] Fac Med, Ctr Neuropsychopharmacol, Div Brain Sci, London, England

[2] Fac Med, Div Brain Sci, C3NL, London, England

[3] Univ London Imperial Coll Sci Technol & Med, Inst Clin Sci, MRC, Psychiat Imaging Grp,Clin Sci Ctr, London, England

[4] UCL, Inst Neurol, London, England

[5] UCL, Clin Psychopharmacol Unit, London, England

[6] Imanova, Ctr Imaging Sci, London, England

[7] Beckley Fdn, Oxford, England

[8] Cardiff Univ, Brain Res Imaging Ctr, Sch Psychol, London, England

[9] Kings Coll London, Sch Biomed Sci, London WC2R 2LS, England

来源：

BIOLOGICAL PSYCHIATRY | 2015年 / 78卷 / 08期

基金：

英国惠康基金;

关键词：

Amygdala; 5-HT; fMRI; Hippocampus; MDMA; PTSD; Serotonin; POSTTRAUMATIC-STRESS-DISORDER; CENTRAL-NERVOUS-SYSTEM; MDMA-ECSTASY; PREFRONTAL CORTEX; NEGATIVE EMOTIONS; MEMORY IMPAIRMENT; HUMANS; RECEPTORS; ANXIETY; PRETREATMENT;

D O I：

10.1016/j.biopsych.2013.12.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BACKGROUND: The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. METHODS: In a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling and seed-based resting state functional connectivity (RSFC) were used to produce spatial maps displaying changes in cerebral blood flow (CBF) and RSFC after MDMA administration. Participants underwent two arterial spin labeling and two blood oxygen level-dependent scans in a 90-minute scan session; MDMA and placebo study days were separated by 1 week. RESULTS: Marked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and hippocampus correlated with ratings of the intensity of global subjective effects of MDMA. The RSFC results complemented the CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex, and MTL regions, and increases between the amygdala and hippocampus. There were trend-level correlations between these effects and ratings of intense and positive subjective effects. CONCLUSIONS: The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug's characteristic subjective effects arise from its modulation of spontaneous brain activity.

引用

页码：554 / 562

页数：9

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