An efficient and regioselective one-pot multi-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in Water

被引：29

作者：

Majumder, Swarup ^{[1
]}

Borah, Pallabi ^{[1
]}

Bhuyan, Pulak J. ^{[1
]}

机构：

[1] CSIR North East Inst Sci &i Technol, Div Med Chem, Jorhat 785006, Assam, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 06期

关键词：

Pyrimido[4,5-d]pyrimidine; Multicomponent reaction; Isothiocyanate; N; N-Dimethyl 6-amino uracil; p-Toluenesulfonic acid (p-TSA); ORGANIC-REACTIONS; SOLVENT; GREEN;

D O I：

10.1016/j.tetlet.2013.12.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrimido[4,5-d]pyrimidine derivatives 4 have been prepared in an efficient and regioselective manner in water via multi-component reaction of isothiocyanate 1, aromatic aldehyde 2, N,N-dimethyl-6-amino uracil 3 in the presence of p-toluenesulfonic acid (p-TSA) as a Lewis acid catalyst. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1168 / 1170

页数：3

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