An efficient and regioselective one-pot multi-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in Water

被引：29
作者：
Majumder, Swarup [1 ]
Borah, Pallabi [1 ]
Bhuyan, Pulak J. [1 ]
机构：
[1] CSIR North East Inst Sci &i Technol, Div Med Chem, Jorhat 785006, Assam, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 06期
关键词：
Pyrimido[4,5-d]pyrimidine; Multicomponent reaction; Isothiocyanate; N; N-Dimethyl 6-amino uracil; p-Toluenesulfonic acid (p-TSA); ORGANIC-REACTIONS; SOLVENT; GREEN;
D O I：
10.1016/j.tetlet.2013.12.095
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyrimido[4,5-d]pyrimidine derivatives 4 have been prepared in an efficient and regioselective manner in water via multi-component reaction of isothiocyanate 1, aromatic aldehyde 2, N,N-dimethyl-6-amino uracil 3 in the presence of p-toluenesulfonic acid (p-TSA) as a Lewis acid catalyst. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1168 / 1170
页数：3
相关论文
共 50 条
  • [21] One-Pot Three-Component Synthesis of Oxazine Derivatives in Water
    Rostami-Charati, Faramarz
    Hossaini, Zinatossadat
    Gharaee, Ebrahim
    Khalilzadeh, Mohammad A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 : E174 - E177
  • [22] ZrCl4 as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions
    Jasem Aboonajmi
    Mir Rasul Mousavi
    Malek Taher Maghsoodlou
    Nourallah Hazeri
    Amin Masoumnia
    Research on Chemical Intermediates, 2015, 41 : 1925 - 1934
  • [23] Glycolic acid-supported cobalt ferrite-catalyzed one-pot synthesis of pyrimido[4,5-b]quinoline and indenopyrido[2,3-d]pyrimidine derivatives
    Gholami, Ahmad
    Mokhtary, Masoud
    Nikpassand, Mohammad
    APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (12)
  • [24] One-pot three-component synthesis of chromeno [2,3-d] pyrimidine derivatives: Novel, simple, and efficient electrochemical approach
    Malviya, Jyoti
    Singh, Rana Krishna Pal
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (01) : 39 - 49
  • [25] Synthesis of substituted pyrimidine usingZnFe2O4nanocatalyst via one pot multi-component reaction ultrasonic irradiation
    Chavan, Pravin
    Bangale, Sachin
    Pansare, Dattatraya
    Shelke, Rohini
    Jadhav, Shivaji
    Tupare, Shrikrushna
    Kamble, Dhanraj
    Rai, Megha
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (09) : 3326 - 3333
  • [26] ONE-POT CHEMOSELECTIVE SYNTHESIS OF NOVEL FUSED PYRIMIDINE DERIVATIVES
    Heravi, M. M.
    Saeedi, M.
    Beheshtiha, Y. S.
    Oskooie, H. A.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2011, 47 (06) : 737 - 744
  • [27] One-pot chemoselective synthesis of novel fused pyrimidine derivatives
    M. M. Heravi
    M. Saeedi
    Y. S. Beheshtiha
    H. A. Oskooie
    Chemistry of Heterocyclic Compounds, 2011, 47 : 737 - 744
  • [28] One-pot, Multi-Component Synthesis of Novel Bis-Spiro Pyranopyrazole Derivatives in the Presence of DABCO as an Efficient and Reusable Solid Base Catalyst
    Safari, Ensieh
    Hasaninejad, Alireza
    CHEMISTRYSELECT, 2018, 3 (12): : 3529 - 3533
  • [29] An Efficient Synthesis of 4H-chromene Derivatives by a One-pot, Three-component Reaction
    Poursattar Marjani, Ahmad
    Ebrahimi Saatluo, Bahman
    Nouri, Fariba
    IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION, 2018, 37 (01): : 149 - 157
  • [30] Multi-Component One-Pot Reactions for the Synthesis of Spirooxindole-pyrano[2,3-c]pyrazole Derivatives
    Feng, Jun
    Ablajan, Keyume
    Ma, Xiabing
    Li, Wenbo
    Obul, Mamateli
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 36 (01) : 222 - 228
12345