Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

被引：165

作者：

Walsh, Jessica J. ^{[1
,2
]}

Friedman, Allyson K. ^{[1
]}

Sun, Haosheng ^{[2
]}

Heller, Elizabeth A. ^{[2
]}

Ku, Stacy M. ^{[1
,2
]}

Juarez, Barbara ^{[1
,2
]}

Burnham, Veronica L. ^{[1
,2
]}

Mazei-Robison, Michelle S. ^{[2
]}

Ferguson, Deveroux ^{[2
]}

Golden, Sam A. ^{[2
]}

Koo, Ja Wook ^{[2
]}

Chaudhury, Dipesh ^{[1
]}

Christoffe, Daniel J. ^{[2
]}

Pomeranz, Lisa ^{[3
]}

Friedman, Jeffrey M. ^{[3
]}

Russo, Scott J. ^{[2
]}

Nestler, Eric J. ^{[1
,2
]}

Han, Ming-Hu ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, Fishberg Dept Neurosci, New York, NY USA

[3] Rockefeller Univ, Howard Hughes Med Inst, Mol Genet Lab, New York, NY 10021 USA

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 01期

关键词：

SOCIAL DEFEAT; DOPAMINERGIC-NEURONS; SUSCEPTIBILITY; CIRCUIT;

D O I：

10.1038/nn.3591

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine reward pathway remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens (NAc) of socially stressed mice but not of stress-naive mice. This stress gating of BDNF signaling is mediated by corticotrophin-releasing factor (CRF) acting in the NAc. These results unravel a stress context-detecting function of the brain's mesolimbic circuit.

引用

页码：27 / 29

页数：3

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