Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes

被引：18

作者：

Sureda, F

Copani, A

Bruno, V

Knopfel, T

Meltzger, G

Nicoletti, F

机构：

[1] IMN, POZZILLI, ITALY

[2] UNIV CATANIA, SCH PHARM, INST PHARMACOL, I-95125 CATANIA, ITALY

[3] IRCCS, ROME, ITALY

[4] CELL CONTROL, MARTINSRIED, GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 338卷 / 02期

关键词：

metabotropic glutamate receptor; hepatocyte; cultured; polyphosphoinositide hydrolysis;

D O I：

10.1016/S0014-2999(97)81950-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabotropic glutamate (mGlu) receptor agonists, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), but not (RS)-3,5-dihydroxyphenylglycine or (2S,3S,45)-alpha-(carboxycyclopropyl)glycine, stimulated [H-3]inositolmonophosphate ([H-3]InsP) formation in primary cultures of rat hepatocytes. 1S,3R-ACPD-stimulated [H-3]InsP formation was inhibited by alpha-methyl-4-carboxyphenylglycine, indicating that cultured hepatocytes express functional mGlu receptors coupled to polyphosphoinositide hydrolysis. The identity of these receptors is not similar to that of any of the known mGlu receptor subtypes characterized in heterologous expression systems. (C) 1997 Elsevier Science B.V.

引用

页码：R1 / R2

页数：2

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