Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia, 2014

被引：72

作者：

Feikin, Daniel R. ^{[1
]}

Alraddadi, Basem ^{[2
,3
]}

Qutub, Mohammed ^{[2
,3
]}

Shabouni, Omaima ^{[2
]}

Curns, Aaron ^{[1
]}

Oboho, Ikwo K. ^{[1
]}

Tomczyk, Sara M. ^{[1
]}

Wolff, Bernard ^{[1
]}

Watson, John T. ^{[1
]}

Madani, Tariq A. ^{[2
,4
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA USA

[2] Minist Hlth, Jeddah, Saudi Arabia

[3] King Faisal Specialist Hosp & Res Ctr, Jeddah, Saudi Arabia

[4] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 11期

关键词：

EAST RESPIRATORY SYNDROME; SYNDROME CORONAVIRUS INFECTION; SYNCYTIAL VIRUS; CLINICAL-COURSE; INFLUENZA; OUTCOMES; VALUES;

D O I：

10.3201/eid2111.150764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) causes a spectrum of illness. We evaluated whether cycle threshold (C-t) values (which are inversely related to virus load) were associated with clinical severity in patients from Saudi Arabia whose nasopharyngeal specimens tested positive for this virus by real-time reverse transcription PCR. Among 102 patients, median C-t of 31.0 for the upstream of the E gene target for 41(40%) patients who died was significantly lower than the median of 33.0 for 61 survivors (p =, 0.0087). In multivariable regression analyses, risk factors for death were age >60 years, underlying illness, and decreasing C-t. Results were similar for a composite severe outcome (death and/or intensive care unit admission). More data are needed to determine whether modulation of virus load by therapeutic agents affects clinical outcomes.

引用

页码：2029 / 2035

页数：7

共 28 条

[1] Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection [J].

Arabi, Yaseen M. ;

Arifi, Ahmed A. ;

Balkhy, Hanan H. ;

Najm, Hani ;

Aldawood, Abdulaziz S. ;

Ghabashi, Alaa ;

Hawa, Hassan ;

Alothman, Adel ;

Khaldi, Abdulaziz ;

Al Raiy, Basel .

ANNALS OF INTERNAL MEDICINE, 2014, 160 (06) :389-+

[2] Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J].

Assiri, Abdullah ;

Al-Tawfiq, Jaffar A. ;

Al-Rabeeah, Abdullah A. ;

Al-Rabiah, Fahad A. ;

Al-Hajjar, Sami ;

Al-Barrak, Ali ;

Flemban, Hesham ;

Al-Nassir, Wafa N. ;

Balkhy, Hanan H. ;

Al-Hakeem, Rafat F. ;

Makhdoom, Hatem Q. ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

LANCET INFECTIOUS DISEASES, 2013, 13 (09) :752-761

[3] Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus [J].

Assiri, Abdullah ;

McGeer, Allison ;

Perl, Trish M. ;

Price, Connie S. ;

Al Rabeeah, Abdullah A. ;

Cummings, Derek A. T. ;

Alabdullatif, Zaki N. ;

Assad, Maher ;

Almulhim, Abdulmohsen ;

Makhdoom, Hatem ;

Madani, Hossam ;

Alhakeem, Rafat ;

Al-Tawfiq, Jaffar A. ;

Cotten, Matthew ;

Watson, Simon J. ;

Kellam, Paul ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) :407-416

[4] Evidence for Camel-to-Human Transmission of MERS Coronavirus [J].

Azhar, Esam I. ;

El-Kafrawy, Sherif A. ;

Farraj, Suha A. ;

Hassan, Ahmed M. ;

Al-Saeed, Muneera S. ;

Hashem, Anwar M. ;

Madani, Tariq A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (26) :2499-2505

[5] Nasal quantity of respiratory syncytial virus correlates with disease severity in hospitalized infants [J].

Buckingham, SC ;

Bush, AJ ;

Devincenzo, JP .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (02) :113-117

[6]

Corman VM, 2012, EUROSURVEILLANCE, V17, P2

[7] Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection [J].

Drosten, Christian ;

Seilmaier, Michael ;

Corman, Victor M. ;

Hartmann, Wulf ;

Scheible, Gregor ;

Sack, Stefan ;

Guggemos, Wolfgang ;

Kallies, Rene ;

Muth, Doreen ;

Junglen, Sandra ;

Muller, Marcel A. ;

Haas, Walter ;

Guberina, Nana ;

Rohnisch, Tim ;

Schmid-Wendtner, Monika ;

Aldabbagh, Souhaib ;

Dittmer, Ulf ;

Gold, Hermann ;

Graf, Petra ;

Bonin, Frank ;

Rambaut, Andrew ;

Wendtner, Clemens-Martin .

LANCET INFECTIOUS DISEASES, 2013, 13 (09) :745-751

[8] Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection [J].

Franz, Anna ;

Adams, Ortwin ;

Willems, Rhea ;

Bonzel, Linda ;

Neuhausen, Nicole ;

Schweizer-Krantz, Susanne ;

Ruggeberg, Jens U. ;

Willers, Reinhart ;

Henrich, Birgit ;

Schroten, Horst ;

Tenenbaum, Tobias .

JOURNAL OF CLINICAL VIROLOGY, 2010, 48 (04) :239-245

[9] Association of the CT values of real-time PCR of viral upper respiratory tract infection with clinical severity, Kenya [J].

Fuller, James A. ;

Njenga, M. Kariuki ;

Bigogo, Godfrey ;

Aura, Barrack ;

Ope, Maurice O. ;

Nderitu, Leonard ;

Wakhule, Lilian ;

Erdman, Dean D. ;

Breiman, Robert F. ;

Feikin, Daniel R. .

JOURNAL OF MEDICAL VIROLOGY, 2013, 85 (05) :924-932

[10] Frequent Detection of Respiratory Viruses without Symptoms: Toward Defining Clinically Relevant Cutoff Values [J].

Jansen, Rogier R. ;

Wieringa, Joanne ;

Koekkoek, Sylvie M. ;

Visser, Caroline E. ;

Pajkrt, Dasja ;

Molenkamp, Richard ;

de Jong, Menno D. ;

Schinkel, Janke .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (07) :2631-2636

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