Resolution of Cheyne-Stokes Respiration after Treatment of Heart Failure with Sacubitril/Valsartan: A First Case Report

被引:12
作者
Fox, Henrik [1 ]
Bitter, Thomas [1 ]
Horstkotte, Dieter [1 ]
Oldenburg, Olaf [1 ]
机构
[1] Ruhr Univ Bochum, Herz & Diabet Zentrum NRW, Clin Cardiol, Georgstr 11, D-32545 Bad Oeynhausen, Germany
关键词
Sacubitril/valsartan; Sleep-disordered breathing; Heart failure; Central sleep apnea; Cheyne-Stokes respiration; Angiotensin receptor-neprilysin inhibitor; CENTRAL SLEEP-APNEA; MORTALITY; PRESSURE; FRIEND; IMPACT; HF;
D O I
10.1159/000455118
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sleep-disordered breathing (SDB) is highly prevalent in patients with heart failure (HF), and is known to be associated with a worse prognosis. The severity of central sleep apnea is thought to mirror cardiac dysfunction. The novel angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril has been shown to improve HF, but a relationship between treatment with ARNi and the severity of SDB has not yet been investigated. We report the case of a 71-year-old male with HF and SDB. Treatment with sacubitril/valsartan was associated with improved cardiac function, as shown by a reduction in the level of N-terminal prohormone of brain natriuretic peptide from 3,249 to 1,720 pg/mL, and an improvement in left-ventricular ejection fraction from 30 to 35%. This was accompanied by a marked reduction in the apnea-hypopnea index (from 41 to 19/h). To the best of our knowledge, this is the first case to document parallel improvements in HF and SDB after the initiation of ARNi treatment. (C) 2017 S. Karger AG, Basel
引用
收藏
页码:96 / 99
页数:4
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