Recent Advances in Organelle-Targeted Fluorescent Probes

被引：65
作者：
Choi, Na-Eun [1 ]
Lee, Ji-Yu [1 ]
Park, Eun-Chae [1 ]
Lee, Ju-Hee [1 ]
Lee, Jiyoun [1 ]
机构：
[1] Sungshin Univ, Dept Next Generat Appl Sci & Global Med Sci, Seoul 01133, South Korea
来源：
MOLECULES | 2021年 / 26卷 / 01期
关键词：
fluorescence imaging; organelle-targeting; chemical probes; DNA MINOR-GROOVE; ENDOPLASMIC-RETICULUM; LYSOSOMOTROPIC AGENTS; HYPOCHLOROUS ACID; MITOCHONDRIA; CELLS; LYSOSOME; VISUALIZATION; LOCALIZATION; MECHANISM;
D O I：
10.3390/molecules26010217
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in fluorescence imaging techniques and super-resolution microscopy have extended the applications of fluorescent probes in studying various cellular processes at the molecular level. Specifically, organelle-targeted probes have been commonly used to detect cellular metabolites and transient chemical messengers with high precision and have become invaluable tools to study biochemical pathways. Moreover, several recent studies reported various labeling strategies and novel chemical scaffolds to enhance target specificity and responsiveness. In this review, we will survey the most recent reports of organelle-targeted fluorescent probes and assess their general strategies and structural features on the basis of their target organelles. We will discuss the advantages of the currently used probes and the potential challenges in their application as well as future directions.
引用
收藏
页数：19
相关论文
共 99 条
[11]   Mitochondrial disease and endocrine dysfunction [J].
Chow, Jasmine ;
Rahman, Joyeeta ;
Achermann, John C. ;
Dattani, Mehul T. ;
Rahman, Shamima .
NATURE REVIEWS ENDOCRINOLOGY, 2017, 13 (02) :92-104
[12]   Two-color nanoscopy of organelles for extended times with HIDE probes [J].
Chu, Ling ;
Tyson, Jonathan ;
Shaw, Juliana E. ;
Rivera-Molina, Felix ;
Koleske, Anthony J. ;
Schepartz, Alanna ;
Toomre, Derek K. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[13]   Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues [J].
Collot, Mayeul ;
Fam, Tkhe Kyong ;
Ashokkumar, Pichandi ;
Faklaris, Orestis ;
Galli, Thierry ;
Danglot, Lydia ;
Klymchenko, Andrey S. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (16) :5401-5411
[14]   An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer [J].
Dahal, Dipendra ;
McDonald, Lucas ;
Bi, Xiaoman ;
Abeywickrama, Chathura ;
Gombedza, Farai ;
Konopka, Michael ;
Paruchuri, Sailaja ;
Pang, Yi .
CHEMICAL COMMUNICATIONS, 2017, 53 (26) :3697-3700
[15]   Fluorescent Flippers for Mechanosensitive Membrane Probes [J].
Dal Molin, Marta ;
Verolet, Quentin ;
Colom, Adai ;
Letrun, Romain ;
Derivery, Emmanuel ;
Gonzalez-Gaitan, Marcos ;
Vauthey, Eric ;
Roux, Aurelien ;
Sakai, Naomi ;
Matile, Stefan .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (02) :568-571
[16]   Targeted fluorescent probes in peroxisome function [J].
Dansen, TB ;
Pap, EHW ;
Wanders, RJA ;
Wirtz, KWA .
HISTOCHEMICAL JOURNAL, 2001, 33 (02) :65-69
[17]   Switchable Solvatochromic Probes for Live-Cell Super-resolution Imaging of Plasma Membrane Organization [J].
Danylchuk, Dmytro, I ;
Moon, Seonah ;
Xu, Ke ;
Klymchenko, Andrey S. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (42) :14920-14924
[18]   Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making [J].
Debie, Pieterjan ;
Hernot, Sophie .
FRONTIERS IN PHARMACOLOGY, 2019, 10
[19]   A general strategy to develop cell membrane fluorescent probes with location- and target-specific fluorogenicities: a case of a Zn2+ probe with cellular selectivity [J].
Deng, Fei ;
Liu, Limin ;
Qiao, Qinglong ;
Huang, Chunfang ;
Miao, Lu ;
Xu, Zhaochao .
CHEMICAL COMMUNICATIONS, 2019, 55 (100) :15045-15048
[20]   Recognition of the DNA minor groove by pyrrole-imidazole polyamides [J].
Dervan, PB ;
Edelson, BS .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2003, 13 (03) :284-299
12345678910