Impact of Induced Pluripotent Stem Cells in Bone Repair and Regeneration

被引：32
|
作者：
Rana, Deepti [1 ]
Kumar, Sanjay [2 ]
Webster, Thomas J. [3 ]
Ramalingam, Murugan [4 ]
机构：
[1] Univ Twente, Tech Med Ctr, Dept Biomech Engn, NL-7522 NB Enschede, Netherlands
[2] Christian Med Coll Campus, Ctr Stem Cell Res, Vellore 632002, Tamil Nadu, India
[3] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
[4] Deemed Univ, Vellore Inst Technol, Ctr Biomat Cellular & Mol Theranost, Biomat & Stem Cell Engn Lab,Sch Mech Engn, Vellore 632014, Tamil Nadu, India
来源：
CURRENT OSTEOPOROSIS REPORTS | 2019年 / 17卷 / 04期
关键词：
Induced pluripotent stem cells (iPSCs); Biomaterials; Osteogenic differentiation; Bone tissue engineering; Bone regeneration; CALCIUM-PHOSPHATE SCAFFOLD; TISSUE; BIOMATERIALS; DESIGN; DEFECT;
D O I：
10.1007/s11914-019-00519-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of ReviewThe main objective of this article is to investigate the current trends in the use of induced pluripotent stem cells (iPSCs) for bone tissue repair and regeneration.Recent FindingsPluripotent stem cell-based tissue engineering has extended innovative therapeutic approaches for regenerative medicine. iPSCs have shown osteogenic differentiation capabilities and would be an innovative resource of stem cells for bone tissue regenerative applications.SummaryThis review recapitulates the current knowledge and recent progress regarding utilization of iPSCs for bone therapy. A review of current findings suggests that a combination of a three-dimensional scaffolding system with iPSC technology to mimic the physiological complexity of the native stem cell niche is highly favorable for bone tissue repair and regeneration.
引用
收藏
页码：226 / 234
页数：9
相关论文
共 50 条
  • [31] Recent Strategies Combining Biomaterials and Stem Cells for Bone, Liver and Skin Regeneration
    Morelli, Sabrina
    Salerno, Simona
    Ahmed, Haysam Mohamed Magdy
    Piscioneri, Antonella
    De Bartolo, Loredana
    CURRENT STEM CELL RESEARCH & THERAPY, 2016, 11 (08) : 676 - 691
  • [32] Stem Cells for Reutilization in Bone Regeneration
    Im, Gun-Il
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2015, 116 (04) : 487 - 493
  • [33] Consideration of Bone Regeneration Effect of Stem Cells: Comparison of Bone Regeneration Between Bone Marrow Stem Cells and Adipose-Derived Stem Cells
    Han, Daniel Seungyoul
    Chang, Hee Kyung
    Kim, Keun Ryoung
    Woo, Sang Min
    JOURNAL OF CRANIOFACIAL SURGERY, 2014, 25 (01) : 196 - 201
  • [34] Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with Human Induced Pluripotent Stem Cells
    Sladkova, Martina
    Cheng, Jiayi
    Palmer, Michael
    Chen, Silvia
    Lin, Charles
    Xia, Wei
    Yu, Yue Eric
    Zhou, Bin
    Engqvist, Hakan
    de Peppo, Giuseppe Maria
    TISSUE ENGINEERING PART A, 2019, 25 (3-4) : 288 - 301
  • [35] Biomaterial aided differentiation and maturation of induced pluripotent stem cells
    Velmurugan, Bharath Kumar
    Priya, Lohanathan Bharathi
    Poornima, Paramasivan
    Lee, Li-Jen
    Baskaran, Rathinasamy
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) : 8443 - 8454
  • [36] Induced pluripotent stem cells as a new getaway for bone tissue engineering: A systematic review
    Bastami, Farshid
    Nazeman, Pantea
    Moslemi, Hamidreza
    Rad, Maryam Rezai
    Sharifi, Kazem
    Khojasteh, Arash
    CELL PROLIFERATION, 2017, 50 (02)
  • [37] Induced Pluripotent Stem Cells: A New Frontier for Stem Cells in Dentistry
    Hynes, K.
    Menichanin, D.
    Bright, R.
    Ivanovski, S.
    Hutmacher, D. W.
    Gronthos, S.
    Bartold, P. M.
    JOURNAL OF DENTAL RESEARCH, 2015, 94 (11) : 1508 - 1515
  • [38] Role of mesenchymal stem cells in bone regeneration and fracture repair: a review
    Wang, Xin
    Wang, Yu
    Gou, Wenlong
    Lu, Qiang
    Peng, Jiang
    Lu, Shibi
    INTERNATIONAL ORTHOPAEDICS, 2013, 37 (12) : 2491 - 2498
  • [39] In vivo bone regeneration using a bioactive nanocomposite scaffold and human mesenchymal stem cells
    Andalib, Nazanin
    Kehtari, Mousa
    Seyedjafari, Ehsan
    Motamed, Nassrin
    Matin, Maryam M.
    CELL AND TISSUE BANKING, 2021, 22 (03) : 467 - 477
  • [40] Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration
    Wang, P.
    Zhao, L.
    Chen, W.
    Liu, X.
    Weir, M. D.
    Xu, H. H. K.
    JOURNAL OF DENTAL RESEARCH, 2014, 93 (07) : 618 - 625
12345