Amino Acid Addiction

被引:5
作者
Blander, J. Magarian [1 ]
Amsen, Derk [2 ]
机构
[1] Mt Sinai Sch Med, Dept Med, Inst Immunol, New York, NY 10029 USA
[2] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol, NL-1105 AZ Amsterdam, Netherlands
关键词
CELLS; STRESS; DIFFERENTIATION; EXPRESSION;
D O I
10.1126/science.1175678
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1282 / 1283
页数:2
相关论文
共 12 条
[1]   Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways [J].
Deval, Christiane ;
Chaveroux, Cedric ;
Maurin, Anne-Catherine ;
Cherasse, Yoan ;
Parry, Laurent ;
Carraro, Valerie ;
Milenkovic, Dragan ;
Ferrara, Marc ;
Bruhat, Alain ;
Jousse, Celine ;
Fafournoux, Pierre .
FEBS JOURNAL, 2009, 276 (03) :707-718
[2]   Regulated translation initiation controls stress-induced gene expression in mammalian cells [J].
Harding, HP ;
Novoa, I ;
Zhang, YH ;
Zeng, HQ ;
Wek, R ;
Schapira, M ;
Ron, D .
MOLECULAR CELL, 2000, 6 (05) :1099-1108
[3]   An integrated stress response regulates amino acid metabolism and resistance to oxidative stress [J].
Harding, HP ;
Zhang, YH ;
Zeng, HQ ;
Novoa, I ;
Lu, PD ;
Calfon, M ;
Sadri, N ;
Yun, C ;
Popko, B ;
Paules, R ;
Stojdl, DF ;
Bell, JC ;
Hettmann, T ;
Leiden, JM ;
Ron, D .
MOLECULAR CELL, 2003, 11 (03) :619-633
[4]   IL-17 and Th17 Cells [J].
Korn, Thomas ;
Bettelli, Estelle ;
Oukka, Mohamed ;
Kuchroo, Vijay K. .
ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :485-517
[5]   IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].
Langrish, CL ;
Chen, Y ;
Blumenschein, WM ;
Mattson, J ;
Basham, B ;
Sedgwick, JD ;
McClanahan, T ;
Kastelein, RA ;
Cua, DJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240
[6]   Creating immune privilege: active local suppression that benefits friends, but protects foes [J].
Mellor, Andrew L. ;
Munn, David H. .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (01) :74-80
[7]   Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma [J].
Pines, A ;
Snyder, D ;
Yarkoni, S ;
Nagler, AN .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2003, 9 (07) :417-425
[8]   Halofuginone Inhibits TH17 Cell Differentiation by Activating the Amino Acid Starvation Response [J].
Sundrud, Mark S. ;
Koralov, Sergei B. ;
Feuerer, Markus ;
Calado, Dinis Pedro ;
Kozhaya, Aimee ElHed ;
Rhule-Smith, Ava ;
Lefebvre, Rachel E. ;
Unutmaz, Derya ;
Mazitschek, Ralph ;
Waldner, Hanspeter ;
Whitman, Malcolm ;
Keller, Tracy ;
Rao, Anjana .
SCIENCE, 2009, 324 (5932) :1334-1338
[9]   Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation [J].
Torchinsky, Miriam Beer ;
Garaude, Johan ;
Martin, Andrea P. ;
Blander, J. Magarian .
NATURE, 2009, 458 (7234) :78-82
[10]   Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells [J].
Veldhoen, Marc ;
Hirota, Keiji ;
Christensen, Jillian ;
O'Garra, Anne ;
Stockinger, Brigitta .
JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (01) :43-49