Disappearance of periodic sharp wave complexes in Creutzfeldt-Jakob disease

被引：8

作者：

Aguglia, U ^{[1
]}

Gambardella, A ^{[1
]}

LePiane, E ^{[1
]}

Messina, D ^{[1
]}

Farnarier, G ^{[1
]}

Oliveri, RL ^{[1
]}

Zappia, M ^{[1
]}

Quattrone, A ^{[1
]}

机构：

[1] HOP NORD MARSEILLE,SERV EXPLORAT FONCTIONNELLES SYST NERVEUX,MARSEILLE,FRANCE

来源：

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY | 1997年 / 27卷 / 04期

关键词：

Creutzfetdt-Jakob disease; periodic sharp wave complexes; electroencephalogram; encephalopathy;

D O I：

10.1016/S0987-7053(97)85825-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Periodic sharp wave complexes (PSWC) are sensitive and specific of Creutzfeldt-Jakob disease (CJD). Once they have emerged, PSWC may exceptionally disappear in the terminal stage of the disease, as a consequence of the flattening of scalp electroencephalogram (EEG). We document the disappearance of PSWC in serial EEG during the clinical course in two women (57 and 70 years of age) with pathologically proven CJD. Despite PSWC disappearance, diffuse theta-delta activity was still well recognizable. Moreover, external stimuli failed to trigger PSWC. The absence of PSWC in CJD might be due to the timing and frequency of EEG recordings. PSWC disappearance should not be interpretated as evidence against the diagnosis of CJD.

引用

页码：277 / 282

页数：6

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