Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

被引：43
作者：
Letort, Sophie
Balieu, Sebastien
Erb, William
Gouhier, Geraldine
Estour, Francois [1 ]
机构：
[1] Normandie Univ, COBRA, UMR 6014, 1 Rue Tesniere, F-76821 Mont St Aignan, France
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷
关键词：
cyclodextrin; enzyme mimic; nerve agents; organophosphorus compounds; pesticides; SUBSTITUTED BETA-CYCLODEXTRIN; IN-VITRO DETOXIFICATION; MULTICENTER PHASE-II; ALPHA-CYCLODEXTRIN; CYCLOSARIN GF; MALIGNANT-MELANOMA; STEREOSPECIFIC REACTION; PHOTODEGRADATION RATES; INCLUSION COMPLEXES; DETOXIFYING AGENTS;
D O I：
10.3762/bjoc.12.23
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical scavengers able to trap and hydrolyze the organophosphorus compounds before they reach their biological target.
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收藏
页码：204 / 228
页数：25
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