Serum Hepcidin-20 is Elevated during the Acute Phase of Myocardial Infarction

被引:32
作者
Suzuki, Hiroshi [2 ]
Toba, Ken [1 ]
Kato, Kiminori [1 ]
Ozawa, Takuya [1 ]
Tomosugi, Naohisa [3 ]
Higuchi, Masato [3 ]
Kusuyama, Taro [2 ]
Iso, Yoshitaka [2 ]
Kobayashi, Naohiko [4 ]
Yokoyama, Sin-ichiro [5 ]
Fukuda, Noboru [5 ]
Saitoh, Hideki [6 ]
Akazawa, Kohei [7 ]
Aizawa, Yoshifusa [1 ]
机构
[1] Niigata Univ, Med & Dent Hosp, Dept Internal Med 1, Niigata 9518510, Japan
[2] Showa Univ, Sch Med, Dept Internal Med 3, Tokyo 142, Japan
[3] Kanazawa Med Univ, Prote Res Unit, Kanazawa, Ishikawa, Japan
[4] Dokkyo Univ, Sch Med, Dept Hypertens & Cardiorenal Med, Mibu, Tochigi 32102, Japan
[5] Nihon Univ, Sch Med, Dept Adv Med, Tokyo, Japan
[6] Chugai Pharmaceut Co Ltd, Tokyo, Japan
[7] Niigata Univ, Med & Dent Hosp, Dept Med Informat, Niigata 9518510, Japan
关键词
Hepcidin; hepcidin-20; iron metabolism; myocardial infarction; proteomics; REGULATORY PEPTIDE HEPCIDIN; ANTIMICROBIAL ACTIVITY; IRON-METABOLISM; INFLAMMATION; ANEMIA; FURIN; HEMOCHROMATOSIS; HYPOFERREMIA; MEDIATOR; HORMONE;
D O I
10.1620/tjem.218.93
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of iron in organs. Hepcidin mRNA and protein are also expressed in the human heart. A short form of hepcidin that lacks 5 amino-acid residues in the N-terminus (hepcidin-20) has been found in human serum, although its physiological role is unknown. Here, we successfully measured the serum levels of hepcidin-25 and hepcidin-20 in 12 patients with acute myocardial infarction (AMI) using surface-enhanced laser desorption ionization time of flight mass spectrometry. Among the selected 10 patients, whose blood samples were taken within 4 hours after a heart attack, all the patients showed elevated serum levels of hepcidin-20 [between 31.7 and 285.1 arbitrary unit (AU); normal level < 9.3 AU], while 8 patients showed high levels of hepcidin-25 (9.3-271.4; normal < 25.5 AU). The hepcidin-20 level was decreased to nearly the normal level on day 7 (range of 2.9 to 12.5 AU) in the 12 patients, whereas the hepcidin-25 level remained high on day 7 in 8 patients. Furthermore, the elevated levels of hepcidin-25 and hepcidin-20 were not correlated with the serum levels of markers for inflammation, interleukin-6 and C-reactive protein, in the patients with AMI. In conclusion, the serum hepcidin-20 is transiently elevated in response to acute cardiac ischemia. Measurement of serum hepcidin-20, rather than hepcidin-25, is helpful for diagnosis of acute myocardial infarction.
引用
收藏
页码:93 / 98
页数:6
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