Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults

被引：152
作者：
Walsh, EE
Falsey, AR
机构：
[1] Rochester Gen Hosp, Dept Med, Rochester, NY 14621 USA
[2] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 02期
关键词：
D O I：
10.1086/421524
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV) infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.
引用
收藏
页码：373 / 378
页数：6
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