Synthesis of Several 5α-Androstano[17,16-d]Pyrazolines from Tigogenin

被引：7

作者：

Nadaraia, N. Sh. ^{[1
]}

Kakhabrishvili, M. L. ^{[1
]}

Onashvili, E. O. ^{[1
]}

Barbakadze, N. N. ^{[1
]}

Getia, M. Z. ^{[1
,2
]}

Pichette, A. ^{[2
]}

Sikharulidze, M. I. ^{[1
]}

Makhmudov, U. S. ^{[3
]}

机构：

[1] Tbilisi State Med Univ, I Kutateladze Inst Pharmaceut Chem, GE-0159 Tbilisi, Georgia

[2] Univ Quebec Chicoutimi, LASEVE, Chicoutimi, PQ G7H 2B1, Canada

[3] Uzbek Acad Sci, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 06期

关键词：

synthesis; 5; alpha-steroids; hydrazines; hydrazones; cyclization; pyrazolines;

D O I：

10.1007/s10600-014-1151-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New androstanopyrazolines and hydrazones were synthesized via acid-catalyzed condensation of the tigogenin transformation product 5 alpha-pregnenolone with several hydrazines. Their structures were proved using IR and NMR spectroscopy and mass spectrometry. An x-ray crystal structure analysis was performed for pregnenolone p-nitrophenylhydrazone acetate.

引用

页码：1024 / 1028

页数：5

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