Autophagy in T-cell differentiation, survival and memory

被引：24

作者：

Wang, Liqing ^{[1
,2
]}

Das, Jugal Kishore ^{[1
]}

Kumar, Anil ^{[1
]}

Peng, Hao-Yun ^{[1
,2
]}

Ren, Yijie ^{[1
]}

Xiong, Xiaofang ^{[1
]}

Yang, Jin-Ming ^{[3
]}

Song, Jianxun ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Microbial Pathogenesis & Immunol, Hlth Sci Ctr, Bryan, TX 77807 USA

[2] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[3] Univ Kentucky, Dept Toxicol & Canc Biol, Coll Med, Lexington, KY USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2021年 / 99卷 / 04期

关键词：

autophagy; differentiation; immunotherapy; memory; survival; T cells; PROTEIN CONJUGATION SYSTEM; CANCER; HOMEOSTASIS; LYMPHOCYTES; METABOLISM; MECHANISMS; RESISTANCE; CLEARANCE; DELETION; MICE;

D O I：

10.1111/imcb.12422

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past decade, autophagy has emerged as a critical regulatory mechanism of the immune system through critically controlling various aspects of T cell biology and determining the fate of different T cell subsets. Autophagy maintains T cell development and survival by regulating the degradation of organelles and apoptotic proteins. The autophagic process also impacts the formation of memory T cells. Alteration of autophagy in T cells may lead to a variety of pathological conditions such as inflammation, autoimmune diseases and cancer. In this review, we discuss how autophagy impacts T cell differentiation, survival and memory, and its implication in immunotherapy for various diseases.

引用

页码：351 / 360

页数：10

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