Tuning cell fate From insights to vertebrate regeneration

被引:6
作者
Kami, Daisuke [1 ]
Gojo, Satoshi [1 ]
机构
[1] Kyoto Prefectural Univ, Dept Regenerat Med, Kyoto 606, Japan
关键词
reprogramming; induced pluripotent stem cells; vertebrate regeneration; transcription factors; pluripotency; dedifferentiation; direct conversion; primed conversion; EMBRYONIC STEM-CELLS; ZEBRAFISH HEART REGENERATION; ADULT HUMAN FIBROBLASTS; SOMATIC-CELLS; DIRECT CONVERSION; DEFINED FACTORS; MOUSE FIBROBLASTS; LIMB REGENERATION; FUNCTIONAL-NEURONS; IN-VITRO;
D O I
10.4161/org.28816
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetic interventions are required to induce reprogramming from one cell type to another. At present, various cellular reprogramming methods such as somatic cell nuclear transfer, cell fusion, and direct reprogramming using transcription factors have been reported. In particular, direct reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) has been achieved using defined factors that play important epigenetic roles. Although the mechanisms underlying cellular reprogramming and vertebrate regeneration, including appendage regeneration, remain unknown, dedifferentiation occurs at an early phase in both the events, and both events are contrasting with regard to cell death. We compared the current status of changes in cell fate of iPSCs with that of vertebrate regeneration and suggested that substantial insights into vertebrate regeneration should be helpful for safe applications of iPSCs to medicine.
引用
收藏
页码:231 / 240
页数:10
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