Oxidative Stress Is Related to Frailty, Not to Age or Sex, in a Geriatric Population: Lipid and Protein Oxidation as Biomarkers of Frailty

被引：125
作者：
Ingles, Marta [1 ]
Gambini, Juan [2 ]
Carnicero, Jose A. [4 ]
Garcia-Garcia, Francisco J. [4 ]
Rodriguez-Manas, Leocadio [5 ]
Olaso-Gonzalez, Gloria [2 ,3 ]
Dromant, Mar [2 ,3 ]
Borras, Consuelo [2 ,3 ]
Vina, Jose [2 ,3 ]
机构：
[1] Univ Valencia, Fac Physiotherapy, Dept Physiotherapy, E-46010 Valencia, Spain
[2] Univ Valencia, Fac Med, Dept Physiol, E-46010 Valencia, Spain
[3] Fdn Invest Hosp Clin Univ INCLIVA, Valencia, Spain
[4] Complejo Hosp Toledo, Hosp Virgen del Valle, Div Geriatr Med, Toledo, OH USA
[5] Hosp Univ Getafe, Fdn Invest Biomed, Madrid, Spain
来源：
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2014年 / 62卷 / 07期
关键词：
elderly; frailty; biomarkers; oxidative damage; LONGEVITY; PLASMA; DAMAGE; MALONDIALDEHYDE; MORTALITY; VALIDITY; DEFICITS; SCALE;
D O I：
10.1111/jgs.12876
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
OBJECTIVES: To ascertain whether indicators of oxidative damage to lipids (malondialdehyde (MDA)) and proteins (protein carbonylation) are biomarkers of frailty, after adjusting for age, sex, and other possible confounders. DESIGN: Cross-sectional cohort study. SETTING: Community. PARTICIPANTS: Toledo Study for Healthy Aging participants (N = 742, aged 65-95), classified as frail (n = 54), prefrail (n = 278) and nonfrail (n = 410) according to the Fried criteria. MEASUREMENTS: Blood plasma was obtained using centrifugation (1,500 G, 15 minutes) and immediately frozen at -80 degrees C. Plasma lipid peroxidation was determined by measuring the MDA formed from lipoperoxides using high-performance liquid chromatography and protein carbonylation was measured using Western blot. RESULTS: Age-and sex-adjusted levels of lipoperoxides (measured as MDA) and protein carbonylation in plasma proved to be related to frailty, even after including possible independent confounders. CONCLUSION: Circulating oxidative damage biomarkers, such as MDA and protein carbonylation, are related to frailty and not to age or sex. These parameters may be considered as potential biomarkers of frailty in the context of a multidisciplinary health-promoting approach for older adults.
引用
收藏
页码：1324 / 1328
页数：5
相关论文
共 28 条
[1]   Frailty: An emerging Geriatric syndrome [J].
Ahmed, Nasiya ;
Mandel, Richard ;
Fain, Mindy J. .
AMERICAN JOURNAL OF MEDICINE, 2007, 120 (09) :748-753
[2]   17β-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFκB cascade [J].
Borrás, C ;
Gambini, J ;
Gómez-Cabrera, MC ;
Sastre, J ;
Pallardó, FV ;
Mann, GE ;
Viña, J .
AGING CELL, 2005, 4 (03) :113-118
[3]   An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples [J].
Breusing, Nicolle ;
Grune, Tilman ;
Andrisic, Luka ;
Atalay, Mustafa ;
Bartosz, Grzegorz ;
Biasi, Fiorella ;
Borovic, Suzana ;
Bravo, Laura ;
Casals, Isidre ;
Casillas, Rosario ;
Dinischiotu, Anca ;
Drzewinska, Joanna ;
Faber, Heidemarie ;
Fauzi, Norsyahida Mohd ;
Gajewska, Agnieszka ;
Gambini, Juan ;
Gradinaru, Daniela ;
Kokkola, Tarja ;
Lojek, Antonin ;
Luczaj, Wojciech ;
Margina, Denisa ;
Mascia, Cinzia ;
Mateos, Raquel ;
Meinitzer, Andreas ;
Teresa Mitjavila, Maria ;
Mrakovcic, Lidija ;
Munteanu, Maria Cristina ;
Podborska, Martina ;
Poli, Giuseppe ;
Sicinska, Paulina ;
Skrzydlewska, Elzbieta ;
Vina, Jose ;
Wiswedel, Ingrid ;
Zarkovic, Neven ;
Zelzer, Sieglinde ;
Spickett, Corinne M. .
FREE RADICAL RESEARCH, 2010, 44 (10) :1203-1215
[4]   Protein carbonyl groups as biomarkers of oxidative stress [J].
Dalle-Donne, I ;
Rossi, R ;
Giustarini, D ;
Milzani, A ;
Colombo, R .
CLINICA CHIMICA ACTA, 2003, 329 (1-2) :23-38
[5]   Oxidative Protein Damage Is Associated With Severe Functional Dependence Among the Elderly Population: A Principal Component Analysis Approach [J].
de Gonzalo-Calvo, David ;
de Luxan-Delgado, Beatriz ;
Rodriguez-Gonzalez, Susana ;
Garcia-Macia, Marina ;
Manuel Suarez, Francisco ;
Jose Solano, Juan ;
Josefa Rodriguez-Colunga, Maria ;
Coto-Montes, Ana .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2012, 67 (06) :663-670
[6]   Frailty in older adults: Evidence for a phenotype [J].
Fried, LP ;
Tangen, CM ;
Walston, J ;
Newman, AB ;
Hirsch, C ;
Gottdiener, J ;
Seeman, T ;
Tracy, R ;
Kop, WJ ;
Burke, G ;
McBurnie, MA .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (03) :M146-M156
[7]   The prevalence of frailty syndrome in an older population from Spain. The Toledo study for healthy aging [J].
Garcia-Garcia, F. J. ;
Gutierrez Avila, G. ;
Alfaro-Acha, A. ;
Amor Andres, M. S. ;
de la Torre Lanza, M. De Los Angeles ;
Escribano Aparicio, M. V. ;
Humanes Aparicio, S. ;
Larrion Zugasti, J. L. ;
Gomez-Serranillo Reus, M. ;
Rodriguez-Artalejo, F. ;
Rodriguez-Manas, L. .
JOURNAL OF NUTRITION HEALTH & AGING, 2011, 15 (10) :852-856
[8]   A SHORT PHYSICAL PERFORMANCE BATTERY ASSESSING LOWER-EXTREMITY FUNCTION - ASSOCIATION WITH SELF-REPORTED DISABILITY AND PREDICTION OF MORTALITY AND NURSING-HOME ADMISSION [J].
GURALNIK, JM ;
SIMONSICK, EM ;
FERRUCCI, L ;
GLYNN, RJ ;
BERKMAN, LF ;
BLAZER, DG ;
SCHERR, PA ;
WALLACE, RB .
JOURNALS OF GERONTOLOGY, 1994, 49 (02) :M85-M94
[9]   AGING - A THEORY BASED ON FREE-RADICAL AND RADIATION-CHEMISTRY [J].
HARMAN, D .
JOURNALS OF GERONTOLOGY, 1956, 11 (03) :298-300
[10]   Oxidative protein damage is associated with poor grip strength among older women living in the community [J].
Howard, Caitlin ;
Ferrucci, Luigi ;
Sun, Kai ;
Fried, Linda P. ;
Walston, Jeremy ;
Varadhan, Ravi ;
Guralnik, Jack M. ;
Semba, Richard D. .
JOURNAL OF APPLIED PHYSIOLOGY, 2007, 103 (01) :17-20
123