First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

被引：135

作者：

Wiederhold, Nathan P. ^{[1
]}

Gil, Veronica Garcia ^{[2
]}

Gutierrez, Felipe ^{[3
,4
]}

Lindner, Jonathan R. ^{[1
]}

Albataineh, Mohammad T. ^{[1
]}

McCarthy, Dora I. ^{[1
]}

Sanders, Carmita ^{[1
]}

Fan, Hongxin ^{[1
]}

Fothergill, Annette W. ^{[1
]}

Sutton, Deanna A. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[2] Hosp Univ La Paz, Madrid, Spain

[3] Phoenix VA Healthcare, Phoenix, VA USA

[4] Univ Arizona, Coll Med, Phoenix, AZ USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2016年 / 54卷 / 01期

关键词：

CHRONIC PULMONARY ASPERGILLOSIS; CELL TRANSPLANT RECIPIENTS; AZOLE RESISTANCE; ITRACONAZOLE RESISTANCE; GLOBAL BURDEN; SURVEILLANCE; GENE; TR46/Y121F/T289A; IDENTIFICATION; ENVIRONMENT;

D O I：

10.1128/JCM.02478-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.

引用

页码：168 / 171

页数：4

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