Profile of SARS-CoV-2

被引:4
作者
Heinz, Franz X. [1 ]
Stiasny, Karin [1 ]
机构
[1] Med Univ Vienna, Ctr Virol, Kinderspitalgasse 15, A-1090 Vienna, Austria
关键词
COVID-19; Coronavirus; Origin and evolution; Vaccines; Antivirals; COVID-19; SPIKE;
D O I
10.1007/s00508-020-01763-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The recent emergence of a new coronavirus (severe acute respiratory syndrome corona-virus-2, SARS-CoV-2) that is transmitted efficiently among humans and can result in serious disease and/or death has become a global threat to public health and economy. In this article, we describe some of the most important characteristics of this new virus (including gaps in our understanding) and provide a perspective of ongoing activities for developing virus-specific countermeasures, such as vaccines and antiviral drugs.
引用
收藏
页码:635 / 644
页数:10
相关论文
共 91 条
[1]   Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers A Randomized Clinical Trial [J].
Abella, Benjamin S. ;
Jolkovsky, Eliana L. ;
Biney, Barbara T. ;
Uspal, Julie E. ;
Hyman, Matthew C. ;
Frank, Ian ;
Hensley, Scott E. ;
Gill, Saar ;
Vogl, Dan T. ;
Maillard, Ivan ;
Babushok, Daria, V ;
Huang, Alexander C. ;
Nasta, Sunita D. ;
Walsh, Jennifer C. ;
Wiletyo, E. Paul ;
Gimotty, Phyllis A. ;
Milone, Michael C. ;
Amaravadi, Ravi K. .
JAMA INTERNAL MEDICINE, 2021, 181 (02) :195-202
[2]   Aging immunity may exacerbate COVID-19 [J].
Akbar, Arne N. ;
Gilroy, Derek W. .
SCIENCE, 2020, 369 (6501) :256-257
[3]   The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development [J].
Alturki, Sana O. ;
Alturki, Sawsan O. ;
Connors, Jennifer ;
Cusimano, Gina ;
Kutzler, Michele A. ;
Izmirly, Abdullah M. ;
Haddad, Elias K. .
FRONTIERS IN IMMUNOLOGY, 2020, 11
[4]   The proximal origin of SARS-CoV-2 [J].
Andersen, Kristian G. ;
Rambaut, Andrew ;
Lipkin, W. Ian ;
Holmes, Edward C. ;
Garry, Robert F. .
NATURE MEDICINE, 2020, 26 (04) :450-452
[5]  
[Anonymous], 2012, Wkly Epidemiol Rec, V87, P461
[6]   A perspective on potential antibody-dependent enhancement of SARS-CoV-2 [J].
Arvin, Ann M. ;
Fink, Katja ;
Schmid, Michael A. ;
Cathcart, Andrea ;
Spreafico, Roberto ;
Havenar-Daughton, Colin ;
Lanzavecchia, Antonio ;
Corti, Davide ;
Virgin, Herbert W. .
NATURE, 2020, 584 (7821) :353-363
[7]   Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium [J].
Boettcher-Friebertshaeuser, Eva ;
Klenk, Hans-Dieter ;
Garten, Wolfgang .
PATHOGENS AND DISEASE, 2013, 69 (02) :87-100
[8]   SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 [J].
Braun, Julian ;
Loyal, Lucie ;
Frentsch, Marco ;
Wendisch, Daniel ;
Georg, Philipp ;
Kurth, Florian ;
Hippenstiel, Stefan ;
Dingeldey, Manuela ;
Kruse, Beate ;
Fauchere, Florent ;
Baysal, Emre ;
Mangold, Maike ;
Henze, Larissa ;
Lauster, Roland ;
Mall, Marcus A. ;
Beyer, Kirsten ;
Roehmel, Jobst ;
Voigt, Sebastian ;
Schmitz, Juergen ;
Miltenyi, Stefan ;
Demuth, Ilja ;
Mueller, Marcel A. ;
Hocke, Andreas ;
Witzenrath, Martin ;
Suttorp, Norbert ;
Kern, Florian ;
Reimer, Ulf ;
Wenschuh, Holger ;
Drosten, Christian ;
Corman, Victor M. ;
Giesecke-Thiel, Claudia ;
Sander, Leif Erik ;
Thiel, Andreas .
NATURE, 2020, 587 (7833) :270-+
[9]   Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions [J].
Bunders, Madeleine J. ;
Altfeld, Marcus .
IMMUNITY, 2020, 53 (03) :487-495
[10]  
Burton DR, 2020, HOST MICROBE, V27, p5 695 698, DOI [10.1016/j.chom.2020.04.022, DOI 10.1016/J.CHOM.2020.04.022]