Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus

被引：13

作者：

Georgiadou, S. ^{[1
]}

Ortiz-Pelaez, A. ^{[2
]}

Simmons, M. M. ^{[2
]}

Windl, O. ^{[2
]}

Dawson, M. ^{[2
]}

Neocleous, P. ^{[1
]}

Papasavva-Stylianou, P. ^{[1
]}

机构：

[1] Vet Serv, Nicosia, Cyprus

[2] Anim & Plant Hlth Agcy, Addlestone, Surrey, England

来源：

EPIDEMIOLOGY AND INFECTION | 2017年 / 145卷 / 02期

关键词：

Cyprus; genetic; goat; resistance; scrapie; POLYMORPHISMS; ASSOCIATION; PRP;

D O I：

10.1017/S0950268816002272

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The results of the study reported here are part of an ongoing integrated research programme aimed at producing additional, robust, evidence on the genetic resistance to classical scrapie in goats, with particular reference to codon 146. The study targeted animals aged 56 years, which were born and raised in infected herds and were being culled for management reasons. A total of 556 animals were tested, and all positive animals (n = 117) were of the susceptible NN genotype. A total of 246 goats heterozygous or homozygous for putatively resistant alleles (S146 and D146) were screened with no positive results. The outcome of this study supports the hypothesis that the D146 and S146 alleles could be used as the basis for a nationwide strategy for breeding for resistance in the Cypriot goat population.

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收藏

页码：326 / 328

页数：3

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